Centrosome aberrations in acute myeloid leukemia are correlated to cytogenetic risk profile
| Abnormality . | Total no. . | Median no. (range) of blasts with abnormal centrosomes in % . | ||
|---|---|---|---|---|
| Numerical . | Structural . | Total . | ||
| Healthy control subjects* | 21 | 0.5 (0.0-2.0) | 4.5 (1.0-7.0) | 5.2 (1.0-8.4) |
| AML patients (total)† | 48 | 10.8 (5.0-24.5) | 24.0 (6.0-72.0) | 35.8 (15.0-83.5) |
| Favorable risk | 5 | 8.5 (3.5-16.0) | 14.0 (9.0-20.0) | 22.5 (16.0-32.0) |
| t(15;17) | 1 | 10.5 | 20.0 | 30.5 |
| t(8;21) | 2 | 5.3 (3.5-7.0) | 11.5 (9.0-14.0) | 16.8 (16.0-17.5) |
| inv(16) | 2 | 12.3 (8.5-16.0) | 15.0 (14.0-16.0) | 27.3 (22.5-32.0) |
| Intermediate risk | 32 | 9.5 (5.0-17.5) | 23.5 (6.0-68.0) | 35.3 (15.0-76.0) |
| No abnormality | 21 | 11.0 (5.0-17.5) | 23.0 (6.0-68.0) | 34.5 (15.0-76.0) |
| +4 | 1 | 12.0 | 31.0 | 43.0 |
| +8 | 2 | 11.3 (7.5-15.0) | 39.5 (36.0-43.0) | 50.5 (50.0-51.0) |
| +9 | 1 | 9.5 | 55.0 | 64.5 |
| +13 | 1 | 6.5 | 29.0 | 35.5 |
| Only structural | 6 | 8.0 (7.5-16.0) | 22.0 (20.0-34.0) | 33.0 (27.5-43.5) |
| Adverse risk | 11 | 14.5 (9.5-24.5) | 34.8 (20.0-72.0) | 50.3 (36.0-83.5) |
| Complex | 6 | 15.5 (9.5-18.0) | 30.5 (25.0-72.0) | 46.8 (38.0-83.5) |
| −5 | 1 | 24.5 | 22.0 | 46.5 |
| −7 | 3 | 14.0 (10.5-14.5) | 50.0 (38.0-67.0) | 64.5 (52.0-77.5) |
| del(5q) | 1 | 16.0 | 20.0 | 36.0 |
| Abnormality . | Total no. . | Median no. (range) of blasts with abnormal centrosomes in % . | ||
|---|---|---|---|---|
| Numerical . | Structural . | Total . | ||
| Healthy control subjects* | 21 | 0.5 (0.0-2.0) | 4.5 (1.0-7.0) | 5.2 (1.0-8.4) |
| AML patients (total)† | 48 | 10.8 (5.0-24.5) | 24.0 (6.0-72.0) | 35.8 (15.0-83.5) |
| Favorable risk | 5 | 8.5 (3.5-16.0) | 14.0 (9.0-20.0) | 22.5 (16.0-32.0) |
| t(15;17) | 1 | 10.5 | 20.0 | 30.5 |
| t(8;21) | 2 | 5.3 (3.5-7.0) | 11.5 (9.0-14.0) | 16.8 (16.0-17.5) |
| inv(16) | 2 | 12.3 (8.5-16.0) | 15.0 (14.0-16.0) | 27.3 (22.5-32.0) |
| Intermediate risk | 32 | 9.5 (5.0-17.5) | 23.5 (6.0-68.0) | 35.3 (15.0-76.0) |
| No abnormality | 21 | 11.0 (5.0-17.5) | 23.0 (6.0-68.0) | 34.5 (15.0-76.0) |
| +4 | 1 | 12.0 | 31.0 | 43.0 |
| +8 | 2 | 11.3 (7.5-15.0) | 39.5 (36.0-43.0) | 50.5 (50.0-51.0) |
| +9 | 1 | 9.5 | 55.0 | 64.5 |
| +13 | 1 | 6.5 | 29.0 | 35.5 |
| Only structural | 6 | 8.0 (7.5-16.0) | 22.0 (20.0-34.0) | 33.0 (27.5-43.5) |
| Adverse risk | 11 | 14.5 (9.5-24.5) | 34.8 (20.0-72.0) | 50.3 (36.0-83.5) |
| Complex | 6 | 15.5 (9.5-18.0) | 30.5 (25.0-72.0) | 46.8 (38.0-83.5) |
| −5 | 1 | 24.5 | 22.0 | 46.5 |
| −7 | 3 | 14.0 (10.5-14.5) | 50.0 (38.0-67.0) | 64.5 (52.0-77.5) |
| del(5q) | 1 | 16.0 | 20.0 | 36.0 |