Results from the linkage analysis: APCR with F5 DNA variants, and APCR conditional on the FVL mutation
| Locus . | DNA variant . | Amino acid change . | Allelic frequencies in the GAIT sample . | LOD score . | |
|---|---|---|---|---|---|
| APCR . | APCR-FVL . | ||||
| FV | — | Ala485Leu | 0.996/0.004 | 0.24 | 0.26 |
| FV | FVL | Arg506Gln | 0.993/0.007 | 2.78 | 0.00 |
| FV | IVS11 | None | 0.222/0.572/0.083/0.122 | 0.00 | 0.00 |
| FV | 2298T > C | None | 0.757/0.243 | 0.00 | 0.00 |
| FV | 2325C > T | None | 0.810/0.189 | 0.00 | 0.00 |
| FV | 2391G > A | None | 0.750/0.250 | 0.00 | 0.00 |
| FV | 2833A > T | None | 0.962/0.038 | 0.00 | 0.00 |
| FV | 4070A > G | His1299Arg | 0.920/0.079 | 0.00 | 0.00 |
| FV | 5380A > G | None | 0.656/0.344 | 0.00 | 0.00 |
| FV | IVS16 | None | 0.049/0.951 | 3.05 | 0.00 |
| Locus . | DNA variant . | Amino acid change . | Allelic frequencies in the GAIT sample . | LOD score . | |
|---|---|---|---|---|---|
| APCR . | APCR-FVL . | ||||
| FV | — | Ala485Leu | 0.996/0.004 | 0.24 | 0.26 |
| FV | FVL | Arg506Gln | 0.993/0.007 | 2.78 | 0.00 |
| FV | IVS11 | None | 0.222/0.572/0.083/0.122 | 0.00 | 0.00 |
| FV | 2298T > C | None | 0.757/0.243 | 0.00 | 0.00 |
| FV | 2325C > T | None | 0.810/0.189 | 0.00 | 0.00 |
| FV | 2391G > A | None | 0.750/0.250 | 0.00 | 0.00 |
| FV | 2833A > T | None | 0.962/0.038 | 0.00 | 0.00 |
| FV | 4070A > G | His1299Arg | 0.920/0.079 | 0.00 | 0.00 |
| FV | 5380A > G | None | 0.656/0.344 | 0.00 | 0.00 |
| FV | IVS16 | None | 0.049/0.951 | 3.05 | 0.00 |
IVS indicates intervening sequence.