Clinical and biologic features of patients with MALT lymphoma and MZL with t(14;18)(q32.3;q21.3) involving MALT1 gene
Case . | Age, y/sex . | Diagnosis . | Status . | Stage (organ involvement) . | Pathologic and cytologic features . | Therapy, evolution . | Cytogenetic analysis . |
|---|---|---|---|---|---|---|---|
| 1 | 76/M | MALT lymphoma, orbital | Diagnosis | Orbital | Low-grade MALT lymphoma | Local RT CR | 47,XY,+3,t(14;18)(q32;q21) [6]/46, XY [3] |
| 2 | 50/F | MZL | Diagnosis | IVB (PB, BM, spleen, lung, pleural effusion) | Splenic MZL: CD5, CD10, CD3, CD23, CD43, FMC7+, CD79B+, CD103, BCL2+, P53, CD20+. IgM+ | SPL + CT; relapsed in 1 y | 48,XX,add(1)(p36),+1,der(1)t(1;17) (p32;q11)t(1;5)(q31;p12),+3, del(10)(p14),t(11;12)(q23;q12), t(14;18)(q32;q21) [6] |
| Transformed MZL | Relapse | IVB (PB, BM, lung, pleural effusion) | PB: 75% blast cells, CD5, CD10, CD3, CD23+, FMC7+, CD79b+, IgM+ | CT + MAb anti-CD20; relapsed, died | 47,XX,+der(1)t(1;17)(p32;q11)t(1;5) (q31;p11),del(10)(p14),t(11;12) (q23;q12),t(14;18)(q32;q21), t(14;19)(q32;p13) [7] |
Case . | Age, y/sex . | Diagnosis . | Status . | Stage (organ involvement) . | Pathologic and cytologic features . | Therapy, evolution . | Cytogenetic analysis . |
|---|---|---|---|---|---|---|---|
| 1 | 76/M | MALT lymphoma, orbital | Diagnosis | Orbital | Low-grade MALT lymphoma | Local RT CR | 47,XY,+3,t(14;18)(q32;q21) [6]/46, XY [3] |
| 2 | 50/F | MZL | Diagnosis | IVB (PB, BM, spleen, lung, pleural effusion) | Splenic MZL: CD5, CD10, CD3, CD23, CD43, FMC7+, CD79B+, CD103, BCL2+, P53, CD20+. IgM+ | SPL + CT; relapsed in 1 y | 48,XX,add(1)(p36),+1,der(1)t(1;17) (p32;q11)t(1;5)(q31;p12),+3, del(10)(p14),t(11;12)(q23;q12), t(14;18)(q32;q21) [6] |
| Transformed MZL | Relapse | IVB (PB, BM, lung, pleural effusion) | PB: 75% blast cells, CD5, CD10, CD3, CD23+, FMC7+, CD79b+, IgM+ | CT + MAb anti-CD20; relapsed, died | 47,XX,+der(1)t(1;17)(p32;q11)t(1;5) (q31;p11),del(10)(p14),t(11;12) (q23;q12),t(14;18)(q32;q21), t(14;19)(q32;p13) [7] |
RT indicates radiotherapy; CR, complete remission; PB, peripheral blood; BM, bone marrow; SPL, splenectomy; and CT, chemotherapy.