Table 3.

Hematologic characteristics of diseased mice given transplants of ND13-Meis1-cotransduced BM cells




Peripheral blood

Blast, %

Spleen
Primary mouse
Disease onset, d
WBC, × 106/mL
RBC, × 109/mL
PB
BM
Weight, g
Experiment 3        
    ND13-Meis1 no. 1*  112   385   2.05   ND   ND   0.39  
Experiment 4        
    ND13-Meis1 no. 2   98   210   1.20   ND   ND   0.58  
    ND13-Meis1 no. 3   110   100   0.85   36.0   49.3   0.31  
    ND13-Meis1 no. 4  88   107   3.05   63.0   80.3   0.41  
    ND13-Meis1 no. 5  88   151   10.0   ND   ND   0.37  
Experiment 5        
    ND13-Meis1 no. 6   65   573   3.65   39.0   62.5   0.51  
    ND13-Meis1 no. 7   61   100   1.3   ND   ND   0.34  
Experiment 6        
    ND13-Meis1 no. 8  64   352   NA   NA   NA   NA  
    ND13-Meis1 no. 9  74   245   0.9   52.1   66.1   0.43  
    ND13-Meis1 no. 10
 
76
 
150
 
1.7
 
27.4
 
57.0
 
0.35
 



Peripheral blood

Blast, %

Spleen
Primary mouse
Disease onset, d
WBC, × 106/mL
RBC, × 109/mL
PB
BM
Weight, g
Experiment 3        
    ND13-Meis1 no. 1*  112   385   2.05   ND   ND   0.39  
Experiment 4        
    ND13-Meis1 no. 2   98   210   1.20   ND   ND   0.58  
    ND13-Meis1 no. 3   110   100   0.85   36.0   49.3   0.31  
    ND13-Meis1 no. 4  88   107   3.05   63.0   80.3   0.41  
    ND13-Meis1 no. 5  88   151   10.0   ND   ND   0.37  
Experiment 5        
    ND13-Meis1 no. 6   65   573   3.65   39.0   62.5   0.51  
    ND13-Meis1 no. 7   61   100   1.3   ND   ND   0.34  
Experiment 6        
    ND13-Meis1 no. 8  64   352   NA   NA   NA   NA  
    ND13-Meis1 no. 9  74   245   0.9   52.1   66.1   0.43  
    ND13-Meis1 no. 10
 
76
 
150
 
1.7
 
27.4
 
57.0
 
0.35
 

ND indicates not determined.

*

Unsorted BM cells injected.

Received a mix of ND13, Meis1, and ND13-Meis1 BM cells.

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