Table 1. Clinical, virologic, and... | American Society of Hematology

Table 1.

Clinical, virologic, and immunologic characteristics of the 16 patients with primary HIV-1 infection

Patient	Age, y	Sex	Days from onset of symptoms	CD4, %	CD4 count, cells/μL	Viremia, copies/mL of plasma		CMV serology	IFN-γ–secreting cells, %^*				Lymphoproliferation (stimulation index)^†
						Viremia, copies/mL of plasma			p55		CMV		Lymphoproliferation (stimulation index)^†
						HIV-1 RNA	CMV DNA		CD4⁺ CCR7⁻	CD4⁺ CCR7⁺	CD4⁺ CCR7⁻	CD4⁺ CCR7⁺	p24	p55	CMV
1	32	M	8	3.5	79	58 081 400	980	IgM	0.37	0.03	4.05	0.09	< 5	< 5	< 5
2	30	M	4	6.5	706	701 000	10 350	IgM	1.62	0.05	2.75	0.05	< 5	< 5	< 5
3	20	M	21	18	591	66 700	361	IgM	0.38	0.08	5.24	0.27	< 5	< 5	< 5
4	28	M	45	11	1500	551 000	1 455	IgM	0.54	0.12	16.57	2.57	ND	< 5	< 5
5	23	M	21	6.8	231	105 000	< 10	IgG	0.12	< 0.03	0.06	0.07	ND	ND	ND
6	34	M	26	19.6	838	400 291	< 10	IgG	< 0.03	< 0.03	< 0.03	< 0.03	< 5	< 5	ND
7	35	M	10	14.6	342	256 667	< 10	IgG	0.10	< 0.03	2.30	0.03	< 5	< 5	ND
8	20	F	7	15.2	468	373 693	< 10	IgG	0.95	0.04	0.56	0.03	< 5	< 5	< 5
9	33	M	35	19.6	435	150 000	< 10	ND	0.06	0.20	0.13	0.14	6	12	< 5
10	27	M	14	12	165	839 000	< 10	IgG	0.07	0.05	0.72	0.12	< 5	< 5	< 5
11	29	M	14	27.5	1005	> 750 000	ND	IgG	ND	ND	ND	ND	ND	ND	ND
12	21	M	14	14.4	153	54 722	< 10	Negative	0.32	0.03	< 0.03	< 0.03	< 5	< 5	< 5
13	33	M	9	51.7	596	26 500 000	< 10	Negative	0.40	0.03	< 0.03	< 0.03	< 5	< 5	< 5
14	33	M	10	18	286	1 190 000	ND	Negative	1.00	0.28	< 0.03	< 0.03	< 5	5.4	< 5
15	34	F	28	10	419	505 000	ND	Negative	ND	ND	ND	ND	ND	ND	ND
16	35	M	12	24	405	4 000 000	ND	Negative	ND	ND	ND	ND	ND	ND	ND

Patient	Age, y	Sex	Days from onset of symptoms	CD4, %	CD4 count, cells/μL	Viremia, copies/mL of plasma		CMV serology	IFN-γ–secreting cells, %^*				Lymphoproliferation (stimulation index)^†
						Viremia, copies/mL of plasma			p55		CMV		Lymphoproliferation (stimulation index)^†
						HIV-1 RNA	CMV DNA		CD4⁺ CCR7⁻	CD4⁺ CCR7⁺	CD4⁺ CCR7⁻	CD4⁺ CCR7⁺	p24	p55	CMV
1	32	M	8	3.5	79	58 081 400	980	IgM	0.37	0.03	4.05	0.09	< 5	< 5	< 5
2	30	M	4	6.5	706	701 000	10 350	IgM	1.62	0.05	2.75	0.05	< 5	< 5	< 5
3	20	M	21	18	591	66 700	361	IgM	0.38	0.08	5.24	0.27	< 5	< 5	< 5
4	28	M	45	11	1500	551 000	1 455	IgM	0.54	0.12	16.57	2.57	ND	< 5	< 5
5	23	M	21	6.8	231	105 000	< 10	IgG	0.12	< 0.03	0.06	0.07	ND	ND	ND
6	34	M	26	19.6	838	400 291	< 10	IgG	< 0.03	< 0.03	< 0.03	< 0.03	< 5	< 5	ND
7	35	M	10	14.6	342	256 667	< 10	IgG	0.10	< 0.03	2.30	0.03	< 5	< 5	ND
8	20	F	7	15.2	468	373 693	< 10	IgG	0.95	0.04	0.56	0.03	< 5	< 5	< 5
9	33	M	35	19.6	435	150 000	< 10	ND	0.06	0.20	0.13	0.14	6	12	< 5
10	27	M	14	12	165	839 000	< 10	IgG	0.07	0.05	0.72	0.12	< 5	< 5	< 5
11	29	M	14	27.5	1005	> 750 000	ND	IgG	ND	ND	ND	ND	ND	ND	ND
12	21	M	14	14.4	153	54 722	< 10	Negative	0.32	0.03	< 0.03	< 0.03	< 5	< 5	< 5
13	33	M	9	51.7	596	26 500 000	< 10	Negative	0.40	0.03	< 0.03	< 0.03	< 5	< 5	< 5
14	33	M	10	18	286	1 190 000	ND	Negative	1.00	0.28	< 0.03	< 0.03	< 5	5.4	< 5
15	34	F	28	10	419	505 000	ND	Negative	ND	ND	ND	ND	ND	ND	ND
16	35	M	12	24	405	4 000 000	ND	Negative	ND	ND	ND	ND	ND	ND	ND

ND indicates not determined.

A percentage of IFN-γ–secreting cells lower than 0.03% was considered negative.

A stimulation index more than 5-fold over the negative control (unstimulated PBMC cultures) was considered positive.