Comparison of total human CD45+ cell engraftment levels, CD34+ cell levels, and human-specific CFU content in bnx and NOD/SCID mice
| . | Total hu CD45+ cells/femur + tibia . | Total hu CD34+cells/femur + tibia . | Hu CFU/100 000 hu CD45+ cells . | Hu LTCIC/100 000 hu CD45+ cells . |
|---|---|---|---|---|
| bnx/hu | ||||
| 1 | 7.6 × 105 | 0 | 290 | ND |
| 2 | 8.2 × 105 | 0 | 820 | 87 |
| 3 | 5.0 × 105 | 0 | 590 | 60 |
| 4 | 1.1 × 106 | 0 | 760 | 115 |
| 5 | 6.4 × 105 | 0 | 480 | 69 |
| 6 | 7.2 × 105 | 0 | 630 | 33 |
| 7 | 1.7 × 106 | 0 | 470 | 45 |
| 8 | 1.6 × 106 | 0 | 400 | ND |
| 9 | 1.0 × 106 | 0 | 490 | ND |
| 10 | 5.0 × 105 | 0 | 670 | ND |
| 11 | 2.4 × 105 | 0 | 830 | 104 |
| 12 | 1.3 × 106 | 0 | 600 | 28 |
| 13 | 6.8 × 105 | 0 | 530 | 61 |
| 14 | 1.6 × 106 | 0 | 170 | ND |
| 15 | 9.2 × 105 | 0 | 300 | ND |
| 16 | 1.0 × 106 | 0 | 570 | ND |
| 17 | 4.2 × 105 | 0 | 560 | ND |
| 18 | 4.4 × 105 | 0 | 1090 | 132 |
| 19 | 6.0 × 105 | 0 | 990 | 96 |
| 20 | 1.5 × 106 | 0 | 120 | ND |
| 21 | 2.3 × 106 | 0 | 130 | ND |
| 22 | 8.0 × 105 | 0 | 880 | 73 |
| 23 | 1.0 × 106 | 0 | 440 | 35 |
| Average | 9.6 × 105± 1 × 105 | 0 | 550 ± 50 | 72.2 ± 9.2 |
| NOD/SCID | ||||
| 1 | 3.8 × 106 | 5.0 × 105 | 190 | 21 |
| 2 | 1.1 × 106 | 4.4 × 105 | 400 | 13 |
| 3 | 7.0 × 106 | 1.3 × 106 | 100 | ND |
| 4 | 1.1 × 107 | 3.0 × 106 | 110 | 9 |
| 5 | 1.5 × 107 | 3.9 × 106 | 90 | ND |
| 6 | 1.5 × 107 | 1.3 × 106 | 80 | ND |
| 7 | 6.7 × 106 | 9.4 × 105 | 130 | 15 |
| 8 | 2.9 × 106 | 5.6 × 105 | 190 | 17 |
| 9 | 3.6 × 106 | 8.8 × 105 | 160 | 12 |
| 10 | 8.2 × 106 | 1.0 × 106 | 80 | ND |
| 11 | 1.3 × 107 | 1.4 × 106 | 80 | ND |
| Average | 7.9 × 106 ± 1.5 × 106 | 2.2 × 106 | 145 ± 30 | 14.5 ± 1.7 |
| . | Total hu CD45+ cells/femur + tibia . | Total hu CD34+cells/femur + tibia . | Hu CFU/100 000 hu CD45+ cells . | Hu LTCIC/100 000 hu CD45+ cells . |
|---|---|---|---|---|
| bnx/hu | ||||
| 1 | 7.6 × 105 | 0 | 290 | ND |
| 2 | 8.2 × 105 | 0 | 820 | 87 |
| 3 | 5.0 × 105 | 0 | 590 | 60 |
| 4 | 1.1 × 106 | 0 | 760 | 115 |
| 5 | 6.4 × 105 | 0 | 480 | 69 |
| 6 | 7.2 × 105 | 0 | 630 | 33 |
| 7 | 1.7 × 106 | 0 | 470 | 45 |
| 8 | 1.6 × 106 | 0 | 400 | ND |
| 9 | 1.0 × 106 | 0 | 490 | ND |
| 10 | 5.0 × 105 | 0 | 670 | ND |
| 11 | 2.4 × 105 | 0 | 830 | 104 |
| 12 | 1.3 × 106 | 0 | 600 | 28 |
| 13 | 6.8 × 105 | 0 | 530 | 61 |
| 14 | 1.6 × 106 | 0 | 170 | ND |
| 15 | 9.2 × 105 | 0 | 300 | ND |
| 16 | 1.0 × 106 | 0 | 570 | ND |
| 17 | 4.2 × 105 | 0 | 560 | ND |
| 18 | 4.4 × 105 | 0 | 1090 | 132 |
| 19 | 6.0 × 105 | 0 | 990 | 96 |
| 20 | 1.5 × 106 | 0 | 120 | ND |
| 21 | 2.3 × 106 | 0 | 130 | ND |
| 22 | 8.0 × 105 | 0 | 880 | 73 |
| 23 | 1.0 × 106 | 0 | 440 | 35 |
| Average | 9.6 × 105± 1 × 105 | 0 | 550 ± 50 | 72.2 ± 9.2 |
| NOD/SCID | ||||
| 1 | 3.8 × 106 | 5.0 × 105 | 190 | 21 |
| 2 | 1.1 × 106 | 4.4 × 105 | 400 | 13 |
| 3 | 7.0 × 106 | 1.3 × 106 | 100 | ND |
| 4 | 1.1 × 107 | 3.0 × 106 | 110 | 9 |
| 5 | 1.5 × 107 | 3.9 × 106 | 90 | ND |
| 6 | 1.5 × 107 | 1.3 × 106 | 80 | ND |
| 7 | 6.7 × 106 | 9.4 × 105 | 130 | 15 |
| 8 | 2.9 × 106 | 5.6 × 105 | 190 | 17 |
| 9 | 3.6 × 106 | 8.8 × 105 | 160 | 12 |
| 10 | 8.2 × 106 | 1.0 × 106 | 80 | ND |
| 11 | 1.3 × 107 | 1.4 × 106 | 80 | ND |
| Average | 7.9 × 106 ± 1.5 × 106 | 2.2 × 106 | 145 ± 30 | 14.5 ± 1.7 |
ND indicates not determined.