Phenotype of HIV tetramer-positive CD8 T cells does not vary significantly with HIV disease status
| . | % of HIV tetramer-positive CD8 T-cells that express . | |||
|---|---|---|---|---|
| CD27 . | CD45RA . | Perforin . | GzmA . | |
| Clinical stage | ||||
| A, n = 11 | 90 | 10 | 13 | 84 |
| B, n = 6 | 82 | 13 | 10 | 86 |
| C, n = 3 | 80 | 46 | 5 | 87 |
| CD4 count, cells/mm3 | ||||
| 500 or more, n = 10 | 87 | 17 | 10 | 88 |
| Less than 500, n = 10 | 88 | 11 | 17 | 67 |
| Plasma viral load, copies/mL | ||||
| Less than 100, n = 7 | 83 | 20 | 5 | 84 |
| 100 or more, n = 12 | 90 | 11 | 11 | 86 |
| . | % of HIV tetramer-positive CD8 T-cells that express . | |||
|---|---|---|---|---|
| CD27 . | CD45RA . | Perforin . | GzmA . | |
| Clinical stage | ||||
| A, n = 11 | 90 | 10 | 13 | 84 |
| B, n = 6 | 82 | 13 | 10 | 86 |
| C, n = 3 | 80 | 46 | 5 | 87 |
| CD4 count, cells/mm3 | ||||
| 500 or more, n = 10 | 87 | 17 | 10 | 88 |
| Less than 500, n = 10 | 88 | 11 | 17 | 67 |
| Plasma viral load, copies/mL | ||||
| Less than 100, n = 7 | 83 | 20 | 5 | 84 |
| 100 or more, n = 12 | 90 | 11 | 11 | 86 |
Median values for the percentages of HIV tetramer-positive cells that stain positively for each of the phenotypic markers are shown for samples classified by CDC disease stage, CD4 count, and plasma viral load. None of the differences between any of the groups were statistically significant. Three donors recognized more than one tetramer; each tetramer-positive population was counted separately in the analysis.