Frequencies of human fetal liver cells able to regenerate lymphomyelopoiesis in NOD/SCID and NOD/SCID-β2m−/− mice and their decrease under conditions used for retroviral transduction
| . | NOD/SCID hosts . | NOD/SCID-β2m−/−hosts . |
|---|---|---|
| Starting cells | 1/7 000 | 1/16 000 |
| (1/2 500-1/18 000) | (1/9 000-1/31 000) | |
| Posttransduction cells | 1/640 000 | 1/300 000 |
| (1/330 000-1/1 300 000) | (1/150 000-1/600 000) | |
| Loss | ∼ 90-fold | ∼ 20-fold |
| . | NOD/SCID hosts . | NOD/SCID-β2m−/−hosts . |
|---|---|---|
| Starting cells | 1/7 000 | 1/16 000 |
| (1/2 500-1/18 000) | (1/9 000-1/31 000) | |
| Posttransduction cells | 1/640 000 | 1/300 000 |
| (1/330 000-1/1 300 000) | (1/150 000-1/600 000) | |
| Loss | ∼ 90-fold | ∼ 20-fold |
All values are expressed per the number of CD34+cells injected. Values in brackets show 95% CIs for data from 34 NOD/SCID mice and 16 NOD/SCID-β2m−/− mice injected with transduced cells, from a total of 3 and 4 experiments, respectively.