Cox regression analysis of survival time from diagnosis in 300 patients with CLL
| Variable . | Hazard ratio for death (95% CI) atVH homology cut-off value . | |
|---|---|---|
| 97% . | 98% . | |
| VH unmutated | 5.27 (2.67-10.40) | 2.91 (1.71-4.95) |
| 17p deletion | 5.53 (2.98-10.26) | 8.19 (4.29-15.65) |
| 11q deletion | — | 1.78 (1.07-2.96) |
| Age | 1.49 (1.18-1.87) | 1.68 (1.33-2.13) |
| LDH | 1.26 (1.10-1.44) | 1.2 (1.05-1.38) |
| WBC | 1.11 (1.06-1.17) | 1.11 (1.05-1.16) |
| Variable . | Hazard ratio for death (95% CI) atVH homology cut-off value . | |
|---|---|---|
| 97% . | 98% . | |
| VH unmutated | 5.27 (2.67-10.40) | 2.91 (1.71-4.95) |
| 17p deletion | 5.53 (2.98-10.26) | 8.19 (4.29-15.65) |
| 11q deletion | — | 1.78 (1.07-2.96) |
| Age | 1.49 (1.18-1.87) | 1.68 (1.33-2.13) |
| LDH | 1.26 (1.10-1.44) | 1.2 (1.05-1.38) |
| WBC | 1.11 (1.06-1.17) | 1.11 (1.05-1.16) |
Hazard ratios and CIs are computed for 10-year increments in age; 50 IU/L increments in LDH; and for 20,000 per cubic millimeter increments in the WBC. Estimated shrinkage factor for the effect of unmutated VH was 0.956 (VH homology ≥97%) and 0.935 (VH homology ≥98%), yielding a corrected estimated hazard ratio of 4.90 (VH homology ≥97%) and 2.71 (VH homology ≥98%).