Incidence of genomic abnormalities in 300 CLL according to the VH mutation status
| Aberration . | All cases no. patients (%) . | VH homology <97% 112 (37) . | VH homology ≥97% 188 (63) . | P* . | VH homology <98% 132 (44) . | VH homology ≥98% 168 (56) . | P . |
|---|---|---|---|---|---|---|---|
| 13q deletion | 167 (56) | 75 (67) | 92 (49) | .003 | 86 (65) | 81 (48) | .004 |
| 13q deletion single | 109 (36) | 60 (54) | 49 (26) | <.001 | 66 (50) | 43 (26) | <.001 |
| 12q trisomy | 52 (17) | 20 (18) | 32 (17) | .88 | 20 (15) | 32 (19) | .44 |
| 11q deletion | 50 (17) | 2 (2) | 48 (26) | <.001 | 5 (4) | 45 (27) | <.001 |
| 17p deletion | 20 (7) | 2 (2) | 18 (10) | .008 | 4 (3) | 16 (10) | .03 |
| 17p or 11q deletion | 68 (22) | 4 (4) | 64 (34) | <.001 | 9 (7) | 59 (35) | <.001 |
| Clonal abnormalities | 246 (82) | 87 (78) | 159 (85) | .16 | 105 (80) | 141 (84) | .37 |
| Aberration . | All cases no. patients (%) . | VH homology <97% 112 (37) . | VH homology ≥97% 188 (63) . | P* . | VH homology <98% 132 (44) . | VH homology ≥98% 168 (56) . | P . |
|---|---|---|---|---|---|---|---|
| 13q deletion | 167 (56) | 75 (67) | 92 (49) | .003 | 86 (65) | 81 (48) | .004 |
| 13q deletion single | 109 (36) | 60 (54) | 49 (26) | <.001 | 66 (50) | 43 (26) | <.001 |
| 12q trisomy | 52 (17) | 20 (18) | 32 (17) | .88 | 20 (15) | 32 (19) | .44 |
| 11q deletion | 50 (17) | 2 (2) | 48 (26) | <.001 | 5 (4) | 45 (27) | <.001 |
| 17p deletion | 20 (7) | 2 (2) | 18 (10) | .008 | 4 (3) | 16 (10) | .03 |
| 17p or 11q deletion | 68 (22) | 4 (4) | 64 (34) | <.001 | 9 (7) | 59 (35) | <.001 |
| Clonal abnormalities | 246 (82) | 87 (78) | 159 (85) | .16 | 105 (80) | 141 (84) | .37 |
Fisher exact test.