Table 1. APC and T-cell costimulatory... | American Society of Hematology

Table 1.

APC and T-cell costimulatory and cell adhesion molecules

APC ligand	T-cell receptor	Function
MHCII	CD4	Coreceptor for MHC class II molecules Binds Lck on cytoplasmic membrane
B7-1 (CD80) B7-2 (CD86)	CD28 (Tp44)	Induces IL-2 production T-cell proliferation Prevents T-cell apoptosis
	CTLA-4 (CD152)	Down-regulates T-cell response Inhibits TCR signaling Possibly induces apoptosis
CD40	CD40L	Induces Ig class switching Activates DCs and macrophages Induces costimulatory molecules on APC
OX40L	OX40²¹	Enhances CD4⁺ T-cell proliferation and cytokine production
B7RP-1	ICOS²²	Acts on CD4⁺cells Modulates cytokine production Involved in Ig class switching
41BBL	41BB (CD137)²³	Enhances CD4⁺ and CD8⁺ T-cell proliferation IFN-γ production
LFA-3 (CD58)	LFA-2 (CD2)²⁴	Mediates adhesion and provides costimulation
ICAM-1 (CD54) ICAM-2 (CD102)	LFA-1²⁵	Mediates adhesion and provides costimulation
LFA-1	ICAM-3 (CD50)²⁶	Mediates adhesion and provides costimulation

APC ligand	T-cell receptor	Function
MHCII	CD4	Coreceptor for MHC class II molecules Binds Lck on cytoplasmic membrane
B7-1 (CD80) B7-2 (CD86)	CD28 (Tp44)	Induces IL-2 production T-cell proliferation Prevents T-cell apoptosis
	CTLA-4 (CD152)	Down-regulates T-cell response Inhibits TCR signaling Possibly induces apoptosis
CD40	CD40L	Induces Ig class switching Activates DCs and macrophages Induces costimulatory molecules on APC
OX40L	OX40²¹	Enhances CD4⁺ T-cell proliferation and cytokine production
B7RP-1	ICOS²²	Acts on CD4⁺cells Modulates cytokine production Involved in Ig class switching
41BBL	41BB (CD137)²³	Enhances CD4⁺ and CD8⁺ T-cell proliferation IFN-γ production
LFA-3 (CD58)	LFA-2 (CD2)²⁴	Mediates adhesion and provides costimulation
ICAM-1 (CD54) ICAM-2 (CD102)	LFA-1²⁵	Mediates adhesion and provides costimulation
LFA-1	ICAM-3 (CD50)²⁶	Mediates adhesion and provides costimulation