Table 1. Cytotoxic effects of bexarotene... | American Society of Hematology

Table 1.

Cytotoxic effects of bexarotene and denileukin diftitox (Ontak) alone and in combination

Cell lines and cells	Expression of IL-2 receptor subunits (baseline)			Cytotoxicity (% survival) bexarotene		Cytotoxicity (% survival) bexarotene + Ontak (10⁻¹² M)
Cell lines and cells	p55_α	p75_β	p64_γ	10⁻¹⁰M bexarotene	10⁻⁸ M bexarotene	10⁻¹² M Ontak	10⁻¹² M Ontak + 10⁻¹⁰ M bexarotene	10⁻¹² M Ontak + 10⁻⁸ M bexarotene
NCI-HUT 102	+++	+++	+++	116	112	56	36	29
CEM	±	−	+++	106	109	85	53	44
Raji	+	−	+++	103	105	104	84	80
CTCL patient	±	−	+++	102	106	83	68	61
CTCL patient	−	−	+++	119	106	80	64	58
B-CLL patient	±	−	+++	103	110	86	71	64

Cell lines and cells	Expression of IL-2 receptor subunits (baseline)			Cytotoxicity (% survival) bexarotene		Cytotoxicity (% survival) bexarotene + Ontak (10⁻¹² M)
Cell lines and cells	p55_α	p75_β	p64_γ	10⁻¹⁰M bexarotene	10⁻⁸ M bexarotene	10⁻¹² M Ontak	10⁻¹² M Ontak + 10⁻¹⁰ M bexarotene	10⁻¹² M Ontak + 10⁻⁸ M bexarotene
NCI-HUT 102	+++	+++	+++	116	112	56	36	29
CEM	±	−	+++	106	109	85	53	44
Raji	+	−	+++	103	105	104	84	80
CTCL patient	±	−	+++	102	106	83	68	61
CTCL patient	−	−	+++	119	106	80	64	58
B-CLL patient	±	−	+++	103	110	86	71	64

All the data represent cell count ± SEM by MTT assay.