Expansion of numbers of BFU-E and CFU-E in BM and spleen of PHZ-treated mice
| . | CFU-E (× 10−4) . | BFU-E (× 10−3) . | ||
|---|---|---|---|---|
| BM . | Spleen . | BM . | Spleen . | |
| (+/+) | 4.3 ± 0.6 | 6.6 ± 1.5 | 4.2 ± 0.5 | 1.3 ± 0.4 |
| PHZ (+/+) | 16.2 ± 1.1 | 256.0 ± 29.0 | 4.4 ± 0.4 | 25.0 ± 2.4 |
| (+/−) | 3.9 ± 1.3 | 4.1 ± 0.8 | 4.2 ± 0.3 | 1.6 ± 0.2 |
| PHZ (+/−) | 4.1 ± 0.9 | 23.0 ± 3.0 | 4.9 ± 0.6 | 11.0 ± 0.8 |
| (−/−) | 4.0 ± 1.3 | 2.4 ± 0.5 | 1.6 ± 0.1 | 1.5 ± 0.2 |
| PHZ (−/−) | 4.1 ± 1.4 | 2.0 ± 0.4 | 4.6 ± 0.3 | 1.7 ± 0.4 |
| . | CFU-E (× 10−4) . | BFU-E (× 10−3) . | ||
|---|---|---|---|---|
| BM . | Spleen . | BM . | Spleen . | |
| (+/+) | 4.3 ± 0.6 | 6.6 ± 1.5 | 4.2 ± 0.5 | 1.3 ± 0.4 |
| PHZ (+/+) | 16.2 ± 1.1 | 256.0 ± 29.0 | 4.4 ± 0.4 | 25.0 ± 2.4 |
| (+/−) | 3.9 ± 1.3 | 4.1 ± 0.8 | 4.2 ± 0.3 | 1.6 ± 0.2 |
| PHZ (+/−) | 4.1 ± 0.9 | 23.0 ± 3.0 | 4.9 ± 0.6 | 11.0 ± 0.8 |
| (−/−) | 4.0 ± 1.3 | 2.4 ± 0.5 | 1.6 ± 0.1 | 1.5 ± 0.2 |
| PHZ (−/−) | 4.1 ± 1.4 | 2.0 ± 0.4 | 4.6 ± 0.3 | 1.7 ± 0.4 |
CFU-E and BFU-E in the BM and spleen of the mice treated with PHZ and killed on day 3 were quantitated by hematopoietic colony-forming assays. Values are means ± SEM from 5 mice in each group. Differences between +/− and −/− and +/+ PHZ-treated mice were statistically significant (P < .0001), as determined by Mann-Whitney U test.