Table 4. Impact of genotype on the... | American Society of Hematology

Table 4.

Impact of genotype on the composite end point, MI alone, and bleeding outcomes in the OPUS study (placebo and treated groups combined)

Allele	Composite end point	MI	Bleeding
COL3A1-1	1.08 (0.74-1.57)	1.51 (0.61-3.74)	0.82 (0.59-1.15)
COL3A1-2	1.13 (0.81-1.58)	1.28 (0.60-2.74)	0.83 (0.60-1.14)
COL3A1-3	1.07 (0.76-1.50)	0.79 (0.35-1.76)	1.44 (1.06-1.97)^4-150
COL3A1-4	0.41 (0.17-1.00)^4-151	0.90 (0.21-3.82)	1.37 (0.82-2.27)

Allele	Composite end point	MI	Bleeding
COL3A1-1	1.08 (0.74-1.57)	1.51 (0.61-3.74)	0.82 (0.59-1.15)
COL3A1-2	1.13 (0.81-1.58)	1.28 (0.60-2.74)	0.83 (0.60-1.14)
COL3A1-3	1.07 (0.76-1.50)	0.79 (0.35-1.76)	1.44 (1.06-1.97)^4-150
COL3A1-4	0.41 (0.17-1.00)^4-151	0.90 (0.21-3.82)	1.37 (0.82-2.27)

Data are presented as relative risk (95% confidence interval) for carriers of the allele shown relative to noncarriers, obtained from a Cox proportional hazards model that adjusted for age, sex, country, and treatment.

F4-150

P = .02.

F4-151

P = .05.

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