Characteristics of high-risk patients
| Parameter . | Historical cohort (n = 26) . | Prospective study (n = 17) . |
|---|---|---|
| Age | 40 (18-55) | 40 (19-51) |
| Underlying disease | ||
| Risk status SR/PR | 2/24 | 4/13 |
| Donor type | ||
| Sib | 15 | 10 |
| MUD | 11 | 7 |
| ATG | 11 | 7 |
| Stem cell source | ||
| Bone marrow | 24 | 14 |
| Peripheral blood | 2 | 3 |
| Graft characteristics | ||
| CD3 (105/kg) | 2.0 (1.0-6.8) | 2.0 (1.0-4.0) |
| CD34 (106/kg) | 1.6 (0.26-4.57) | 1.7 (0.53-8.10) |
| Parameter . | Historical cohort (n = 26) . | Prospective study (n = 17) . |
|---|---|---|
| Age | 40 (18-55) | 40 (19-51) |
| Underlying disease | ||
| Risk status SR/PR | 2/24 | 4/13 |
| Donor type | ||
| Sib | 15 | 10 |
| MUD | 11 | 7 |
| ATG | 11 | 7 |
| Stem cell source | ||
| Bone marrow | 24 | 14 |
| Peripheral blood | 2 | 3 |
| Graft characteristics | ||
| CD3 (105/kg) | 2.0 (1.0-6.8) | 2.0 (1.0-4.0) |
| CD34 (106/kg) | 1.6 (0.26-4.57) | 1.7 (0.53-8.10) |
High-risk, as defined by (1) allogeneic stem cell transplantation by partial T-cell depletion, and (2) Epstein-Barr virus load ≥ 1000 geq/mL.
SR/PR indicates standard-risk/poor-risk disease; Sib, HLA-genotypically matched sibling donor; MUD, matched unrelated donor; ATG, antithymocyte globulin.