Preemptive rituximab after T-cell-depleted allogeneic stem cell transplantation for prevention of Epstein-Barr virus-lymphoproliferative disease
Patient no. . | Donor type . | EBV ≥ 1 000 geq/mL . | Initiation of preemptive rituximab (d*) . | Max EBV-DNA level (geq/mL) . | EBV < 50 (geq/mL, d after start preemptive rituximab) . | EBV-LPD . | |
---|---|---|---|---|---|---|---|
Day of onset* . | EBV load . | ||||||
1 | Sib | 73 | 2 700 | 84 | 5 800 | 12 | − |
2 | Sib | 122 | 2 300 | 129 | 2 300 | 6 | − |
3 | Sib | 150 | 1 400 | 157 | 2 800 | 14 | − |
4 | Sib | 188 | 2 100 | 202 | 3 800 | 5 | − |
5 | MUD | 47 | 3 300 | 50 | 1 100 000 | 46 | + |
6 | MUD | 39 | 8 800 | 43 | 675 000 | 45 | − |
7 | Sib | 129 | 14 000 | 133 | 85 000 | 6 | − |
8 | Sib | 108 | 1 400 | 110 | 1 400 | 7 | − |
9 | Sib | 171 | 3 000 | 174 | 110 000 | 26 | − |
10 | MUD | 118 | 1 800 | 125 | 1 800 | 27 | − |
11 | MUD | 46 | 2 100 | 47 | 2 100 | 1 | − |
12 | Sib | 61 | 3 600 | 63 | 3 600 | 4 | − |
13 | Sib | 112 | 1 800 | 113 | 15 000 | 8 | − |
14 | MUD | 40 | 500 | 41 | 1 350 | 21 | − |
15 | Sib | 189 | 1 200 | 192 | 1 150 | 4 | − |
Patient no. . | Donor type . | EBV ≥ 1 000 geq/mL . | Initiation of preemptive rituximab (d*) . | Max EBV-DNA level (geq/mL) . | EBV < 50 (geq/mL, d after start preemptive rituximab) . | EBV-LPD . | |
---|---|---|---|---|---|---|---|
Day of onset* . | EBV load . | ||||||
1 | Sib | 73 | 2 700 | 84 | 5 800 | 12 | − |
2 | Sib | 122 | 2 300 | 129 | 2 300 | 6 | − |
3 | Sib | 150 | 1 400 | 157 | 2 800 | 14 | − |
4 | Sib | 188 | 2 100 | 202 | 3 800 | 5 | − |
5 | MUD | 47 | 3 300 | 50 | 1 100 000 | 46 | + |
6 | MUD | 39 | 8 800 | 43 | 675 000 | 45 | − |
7 | Sib | 129 | 14 000 | 133 | 85 000 | 6 | − |
8 | Sib | 108 | 1 400 | 110 | 1 400 | 7 | − |
9 | Sib | 171 | 3 000 | 174 | 110 000 | 26 | − |
10 | MUD | 118 | 1 800 | 125 | 1 800 | 27 | − |
11 | MUD | 46 | 2 100 | 47 | 2 100 | 1 | − |
12 | Sib | 61 | 3 600 | 63 | 3 600 | 4 | − |
13 | Sib | 112 | 1 800 | 113 | 15 000 | 8 | − |
14 | MUD | 40 | 500 | 41 | 1 350 | 21 | − |
15 | Sib | 189 | 1 200 | 192 | 1 150 | 4 | − |
Days after stem cell transplantation.
Sib indicates HLA genotypically matched sibling donor; MUD, matched unrelated donor; EBV, Epstein-Barr virus; geq/mL, genome equivalents/milliliter; EBV-LPD, EBV-lymphoproliferative disease.