Incidence of chromosomal abnormalities in patients with and without deletions upon development of blast crisis
| Cytogenetic characteristics . | Deletion status . | |
|---|---|---|
| Nondeleted (%) (n = 68) . | Deleted (%) (n = 16) . | |
| Any abnormality | 51 (75) | 12 (75) |
| Extra Ph+ | 12 (18) | 2 (12) |
| Trisomy 8 | 9 (14) | 3 (18) |
| Loss of 17p | 8 (13) | 2 (12) |
| Trisomy 19 | 5 (8) | 1 (6) |
| Trisomy 21 | 5 (8) | 0 |
| del13(q) | 3 (5) | 0 |
| Marker | 5 (8) | 3 (18) |
| Total changes per patient, mean/median | 2.2/1.0 | 1.9/2.0 |
| Double-stranded breaks per patient, mean/median | 0.9/1.0 | 1.1/1.0 |
| Cytogenetic characteristics . | Deletion status . | |
|---|---|---|
| Nondeleted (%) (n = 68) . | Deleted (%) (n = 16) . | |
| Any abnormality | 51 (75) | 12 (75) |
| Extra Ph+ | 12 (18) | 2 (12) |
| Trisomy 8 | 9 (14) | 3 (18) |
| Loss of 17p | 8 (13) | 2 (12) |
| Trisomy 19 | 5 (8) | 1 (6) |
| Trisomy 21 | 5 (8) | 0 |
| del13(q) | 3 (5) | 0 |
| Marker | 5 (8) | 3 (18) |
| Total changes per patient, mean/median | 2.2/1.0 | 1.9/2.0 |
| Double-stranded breaks per patient, mean/median | 0.9/1.0 | 1.1/1.0 |
The prevalence of abnormalities was similar in patients with and without deletions, and the type of changes are consistent with those previously described following progression to blast crisis.26 There were no differences in the proportion of patients with secondary changes by Fisher exact test (P= 1.00) or in the total number of changes or double-stranded breaks by Mann-Whitney U test (P = .86 andP = .62, respectively) between patients with and without deletions.
Ph indicates Philadelphia chromosome.