Outcome measures of bcl-2 positive versus germline FL and impact of additional genetic alterations
| Country . | Outcome parameters, bcl-2 versus germline . | Impact of additional genetic changes . | ||
|---|---|---|---|---|
| CR . | PFS . | OS . | ||
| United States113 | NS | NS6-150 | NS | Chromosome 17: decreased CR rate (P < .01) |
| United States99 | — | — | Lower (P = .02) | del17, dup2: trend to worse outcome |
| dup3 or + 3: trend to better outcome | ||||
| Denmark93 | — | — | NS | — |
| France114 | — | — | NS | Abnormal CG: worse outcome, including: 1p21-22 (P < .01), 6q23-6 (P < .001), 17p (P < .001), no. chromosome breaks > 6 (P < .01) |
| Sweden89 | — | — | Higher (P = .011) | — |
| United States132 | — | — | NS | Bcl-611 patients (9 of whom + bcl-2): OS better thanbcl-6 germline |
| United States83 | Lower | Lower | NS | — |
| Canada97 | — | NS | NS | Increased rate trisomy3 in bcl-2 −ve (P < .01), trend del10q in bcl-2 +ve (P = .08) |
| United States96 | — | — | NS | 17p reduced 5-year OS (P = .058), + 21 (P = .013) reduced 5-year OS |
| United States115 | — | — | NS | Any of + 7/+ 12/1p: decreased median survival (P = .028) |
| Country . | Outcome parameters, bcl-2 versus germline . | Impact of additional genetic changes . | ||
|---|---|---|---|---|
| CR . | PFS . | OS . | ||
| United States113 | NS | NS6-150 | NS | Chromosome 17: decreased CR rate (P < .01) |
| United States99 | — | — | Lower (P = .02) | del17, dup2: trend to worse outcome |
| dup3 or + 3: trend to better outcome | ||||
| Denmark93 | — | — | NS | — |
| France114 | — | — | NS | Abnormal CG: worse outcome, including: 1p21-22 (P < .01), 6q23-6 (P < .001), 17p (P < .001), no. chromosome breaks > 6 (P < .01) |
| Sweden89 | — | — | Higher (P = .011) | — |
| United States132 | — | — | NS | Bcl-611 patients (9 of whom + bcl-2): OS better thanbcl-6 germline |
| United States83 | Lower | Lower | NS | — |
| Canada97 | — | NS | NS | Increased rate trisomy3 in bcl-2 −ve (P < .01), trend del10q in bcl-2 +ve (P = .08) |
| United States96 | — | — | NS | 17p reduced 5-year OS (P = .058), + 21 (P = .013) reduced 5-year OS |
| United States115 | — | — | NS | Any of + 7/+ 12/1p: decreased median survival (P = .028) |
CR indicates complete remission; PFS, progression-free survival; and OS, overall survival.
Failure-free survival.