Frequency of bcl-2 gene rearrangement in follicular NHL from different geographic regions
| Region and author . | No. patients evaluable . | MBR+ (%) . | mcr+ (%) . | Total bcl-2+ (%) . |
|---|---|---|---|---|
| Asia | ||||
| Mitani et al92 | 304-150 | 12 (40) | 1 (3) | 13 (43) |
| Loke et al4-15185 | 16 | 8 (50) | 1 (6) | 9 (56) |
| Subtotal (percentage; 95% CI) | 46 | 20 (43; 29-59) | 2 (4; 0.5-15) | 22 (48; 33-63) |
| Europe | ||||
| Benitez et al86 | 5 | 3 (60) | 0 (0) | 3 (60) |
| Pezzella et al93 | 51 | 18 (35) | 3 (6) | 21 (41) |
| Lee et al91 | 20 | 7 (35) | 1 (5) | 8 (40) |
| Lambrechts et al90 | 21 | 12 (57) | 1 (5) | 13 (62) |
| Poetsch et al66 | 28 | 18 (64) | 0 (0) | 18 (64) |
| Séité et al47 | 64 | 30 (47) | 8 (13) | 38 (59) |
| Johnson et al89 | 50 | 30 (60) | 0 (0) | 30 (60) |
| Subtotal (percentage; 95% CI) | 239 | 118 (49; 43-56) | 13 (5; 3-9) | 131 (55; 48-61) |
| United States | ||||
| Zelenetz et al94 | 40 | 22 (55) | 6 (15) | 28 (70) |
| Liu et al84 | 48 | 24 (50) | 5 (10) | 29 (60) |
| Gribben et al87 | 88 | 56 (64) | 18 (20) | 74 (84) |
| Gulley et al88 | 8 | 4 (50) | 1 (12) | 5 (62) |
| Lopez-Guillermo et al83 | 139 | 105 (70) | 13 (9) | 118 (79) |
| Subtotal (percentage; 95% CI) | 323 | 211 (65; 60-70) | 43 (13; 10-17) | 254 (79; 74-83) |
| Region and author . | No. patients evaluable . | MBR+ (%) . | mcr+ (%) . | Total bcl-2+ (%) . |
|---|---|---|---|---|
| Asia | ||||
| Mitani et al92 | 304-150 | 12 (40) | 1 (3) | 13 (43) |
| Loke et al4-15185 | 16 | 8 (50) | 1 (6) | 9 (56) |
| Subtotal (percentage; 95% CI) | 46 | 20 (43; 29-59) | 2 (4; 0.5-15) | 22 (48; 33-63) |
| Europe | ||||
| Benitez et al86 | 5 | 3 (60) | 0 (0) | 3 (60) |
| Pezzella et al93 | 51 | 18 (35) | 3 (6) | 21 (41) |
| Lee et al91 | 20 | 7 (35) | 1 (5) | 8 (40) |
| Lambrechts et al90 | 21 | 12 (57) | 1 (5) | 13 (62) |
| Poetsch et al66 | 28 | 18 (64) | 0 (0) | 18 (64) |
| Séité et al47 | 64 | 30 (47) | 8 (13) | 38 (59) |
| Johnson et al89 | 50 | 30 (60) | 0 (0) | 30 (60) |
| Subtotal (percentage; 95% CI) | 239 | 118 (49; 43-56) | 13 (5; 3-9) | 131 (55; 48-61) |
| United States | ||||
| Zelenetz et al94 | 40 | 22 (55) | 6 (15) | 28 (70) |
| Liu et al84 | 48 | 24 (50) | 5 (10) | 29 (60) |
| Gribben et al87 | 88 | 56 (64) | 18 (20) | 74 (84) |
| Gulley et al88 | 8 | 4 (50) | 1 (12) | 5 (62) |
| Lopez-Guillermo et al83 | 139 | 105 (70) | 13 (9) | 118 (79) |
| Subtotal (percentage; 95% CI) | 323 | 211 (65; 60-70) | 43 (13; 10-17) | 254 (79; 74-83) |