Table 1.

In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptosis in childhood T-ALL

Bivariate correlationDexamethasone-induced apoptosisDoxorubicin-induced apoptosis
rSPnrSPn
CD marker expression*       
 CD1a 0.30 .006 81 0.40 .000 81 
 CD2 0.19 .089 81 0.26 .020 81  
 Surface CD3 0.26 .018 81 0.08 .455 81 
 CD13 −0.27 .014 81 −0.08 .471 81 
 CD33 −0.16 .149 81 −0.08 .479 81 
 CD34 −0.23 .040 81 −0.25 .025 81 
Constitutive expression of
 apoptosis-related molecules† 		      
 Bcl-2 −0.19 .17 58 −0.04 .776 58 
 Bax 0.14 .288 58 −0.16 .245 58  
 Bcl-2/Bax ratio −0.25 .063 58 0.03 .847 58 
 CD95 −0.21 .139 51 0.04 .758 51  
Functional in vitro apoptosis tests       
 Spontaneous apoptosis 0.25 .026 81 0.34 .002 81  
 IL-7 rescue 0.40 .000 77 0.20 .084 77  
 CD95 sensitivity 0.03 .829 51 0.11 .443 51 
Bivariate correlationDexamethasone-induced apoptosisDoxorubicin-induced apoptosis
rSPnrSPn
CD marker expression*       
 CD1a 0.30 .006 81 0.40 .000 81 
 CD2 0.19 .089 81 0.26 .020 81  
 Surface CD3 0.26 .018 81 0.08 .455 81 
 CD13 −0.27 .014 81 −0.08 .471 81 
 CD33 −0.16 .149 81 −0.08 .479 81 
 CD34 −0.23 .040 81 −0.25 .025 81 
Constitutive expression of
 apoptosis-related molecules† 		      
 Bcl-2 −0.19 .17 58 −0.04 .776 58 
 Bax 0.14 .288 58 −0.16 .245 58  
 Bcl-2/Bax ratio −0.25 .063 58 0.03 .847 58 
 CD95 −0.21 .139 51 0.04 .758 51  
Functional in vitro apoptosis tests       
 Spontaneous apoptosis 0.25 .026 81 0.34 .002 81  
 IL-7 rescue 0.40 .000 77 0.20 .084 77  
 CD95 sensitivity 0.03 .829 51 0.11 .443 51 

Bivariate analyses (Spearman correlation coefficient rS) for maturation-dependent CD markers, apoptosis-related molecules, and functional in vitro apoptosis tests.

*

Percent of positive cells/sample.

†

In MESF (× 10−3).

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