Lymphoid phenotype of relevant knockout mice and SCID syndromes associated with human mutations
| Knockout mouse . | Affected cytokine . | Phenotype . | Human correlate . |
|---|---|---|---|
| γc, Jak 3 | IL-2, IL-4, IL-7, IL-9, IL-15, IL-21 | Impaired T- and B-cell development; absent NK cells; normal thymic architecture | T−, NK−, B+ SCID |
| γc, c-kit | IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, SCF | Similar to γc but complete lack of thymic development | None |
| IL-7 | IL-7 | Impaired T- and B-cell development; normal NK; γδ T cells nearly absent | Unknown |
| IL-7Rα | IL-7, TSLP | More severe impairment of T- and B-cell development than IL-7 knockout; no γδ T cells | T−, NK+, B+ SCID |
| Knockout mouse . | Affected cytokine . | Phenotype . | Human correlate . |
|---|---|---|---|
| γc, Jak 3 | IL-2, IL-4, IL-7, IL-9, IL-15, IL-21 | Impaired T- and B-cell development; absent NK cells; normal thymic architecture | T−, NK−, B+ SCID |
| γc, c-kit | IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, SCF | Similar to γc but complete lack of thymic development | None |
| IL-7 | IL-7 | Impaired T- and B-cell development; normal NK; γδ T cells nearly absent | Unknown |
| IL-7Rα | IL-7, TSLP | More severe impairment of T- and B-cell development than IL-7 knockout; no γδ T cells | T−, NK+, B+ SCID |