Univariate survival analysis in MDS and AML patients
| Variable . | MDS . | AML . | ||
|---|---|---|---|---|
| N . | P . | N . | P . | |
| Age | 279 | .02 | 523 | < .00001 |
| Poor prognosis cytogenetics (-5, -7, 11q23) | 279 | < .00001 | 523 | < .00001 |
| Platelets | 279 | .0017 | 523 | .5 |
| BM cellularity | 279 | .2 | 523 | .66 |
| Absolute lymphocytes | 279 | .4 | 523 | .20 |
| AHD | 279 | .089 | 523 | < .00001 |
| WBC | 279 | .5 | 523 | .08 |
| BM blasts | 279 | .66 | 523 | .5 |
| Caspase 3 | 36 | .9 | 54 | .8 |
| IL-6 | 43 | .83 | 71 | .0004 |
| Treatment arm | 278 | .0005 | 520 | .0002 |
| Variable . | MDS . | AML . | ||
|---|---|---|---|---|
| N . | P . | N . | P . | |
| Age | 279 | .02 | 523 | < .00001 |
| Poor prognosis cytogenetics (-5, -7, 11q23) | 279 | < .00001 | 523 | < .00001 |
| Platelets | 279 | .0017 | 523 | .5 |
| BM cellularity | 279 | .2 | 523 | .66 |
| Absolute lymphocytes | 279 | .4 | 523 | .20 |
| AHD | 279 | .089 | 523 | < .00001 |
| WBC | 279 | .5 | 523 | .08 |
| BM blasts | 279 | .66 | 523 | .5 |
| Caspase 3 | 36 | .9 | 54 | .8 |
| IL-6 | 43 | .83 | 71 | .0004 |
| Treatment arm | 278 | .0005 | 520 | .0002 |
Except for platelets, all significant variables had negative effects on survival. Treatment arms were IA, TA, and FAI. Longer survival was observed in the IA arm, whereas no difference was observed between the TA and FAI arms.