Characteristics of MDS and AML groups
| Variable . | MDS . | AML . | P . | ||
|---|---|---|---|---|---|
| N . | Median (range) . | N . | Median (range) . | ||
| Age, y | 279 | 63 (19-84) | 523 | 59 (16-87) | .0005 |
| WBC count, × 109/L | 279 | 4.7 (0.4-124.5) | 523 | 10.4 (0.2-437) | < .00001 |
| Platelets, × 109/L | 279 | 40 (2-492) | 523 | 49 (1-2292) | .001 |
| Hemoglobin, g/dL | 279 | 7.8 (1.7-15.1) | 523 | 7.9 (2.8-15) | .54 |
| BM cellularity, % | 255 | 60 (5-100) | 502 | 75 (5-100) | .001 |
| Absolute lymphocytes, × 109/L | 279 | 1378 (54-34 486) | 523 | 1900 (0-28 425) | .00005 |
| HGF, pg/mL | 42 | 843.5 (192.3-8 657.4) | 59 | 854.8 (101.9-12 819.5) | .5 |
| TNF-α, pg/mL | 42 | 8.7 (7.1-48.2) | 59 | 9.1 (7.2-18.8) | .32 |
| AHD, mo | 279 | 3 (0-96) | 523 | 0 (0-168) | < .00001 |
| β2-microglobulin, mg/L | 181 | 2.7 (0.8-12) | 333 | 2.6 (0-31.3) | .72 |
| BM blasts, % | 279 | 10 (0-29) | 519 | 50 (2-97) | < .00001 |
| Telomerase | 29 | 948 (0-25 625) | 50 | 876 (0-13 868) | .67 |
| Caspase 3 | 36 | 4.1 (0-16.6) | 54 | 1.2 (0-22.3) | .04 |
| Performance status 0-2 | 279 | 93% | 523 | 88% | .01 |
| Poor prognosis cytogenetics | 279 | 48% | 523 | 35% | .001 |
| Variable . | MDS . | AML . | P . | ||
|---|---|---|---|---|---|
| N . | Median (range) . | N . | Median (range) . | ||
| Age, y | 279 | 63 (19-84) | 523 | 59 (16-87) | .0005 |
| WBC count, × 109/L | 279 | 4.7 (0.4-124.5) | 523 | 10.4 (0.2-437) | < .00001 |
| Platelets, × 109/L | 279 | 40 (2-492) | 523 | 49 (1-2292) | .001 |
| Hemoglobin, g/dL | 279 | 7.8 (1.7-15.1) | 523 | 7.9 (2.8-15) | .54 |
| BM cellularity, % | 255 | 60 (5-100) | 502 | 75 (5-100) | .001 |
| Absolute lymphocytes, × 109/L | 279 | 1378 (54-34 486) | 523 | 1900 (0-28 425) | .00005 |
| HGF, pg/mL | 42 | 843.5 (192.3-8 657.4) | 59 | 854.8 (101.9-12 819.5) | .5 |
| TNF-α, pg/mL | 42 | 8.7 (7.1-48.2) | 59 | 9.1 (7.2-18.8) | .32 |
| AHD, mo | 279 | 3 (0-96) | 523 | 0 (0-168) | < .00001 |
| β2-microglobulin, mg/L | 181 | 2.7 (0.8-12) | 333 | 2.6 (0-31.3) | .72 |
| BM blasts, % | 279 | 10 (0-29) | 519 | 50 (2-97) | < .00001 |
| Telomerase | 29 | 948 (0-25 625) | 50 | 876 (0-13 868) | .67 |
| Caspase 3 | 36 | 4.1 (0-16.6) | 54 | 1.2 (0-22.3) | .04 |
| Performance status 0-2 | 279 | 93% | 523 | 88% | .01 |
| Poor prognosis cytogenetics | 279 | 48% | 523 | 35% | .001 |
Telomerase activity was measured by an arbitrary unit as defined in Verstovsek et al43. Caspase 3 activity was normalized to the average detected in normal control, which was assigned a value of 1.