Hematologic abnormalities during treatment with imatinib
| Abnormality6-150 . | All patients (n = 260) . | 400-mg-dose group (n = 37) . | 600-mg-dose group (n = 223) . |
|---|---|---|---|
| Anemia | |||
| Grade 36-151 | 106 (41) | 16 (43) | 90 (40) |
| Grade 46-151 | 29 (11) | 6 (16) | 23 (10) |
| Neutropenia | |||
| Grade 36-151 | 41 (16) | 5 (14) | 36 (16) |
| Grade 46-151 | 124 (48) | 20 (54) | 104 (47) |
| Median duration, d (range)6-152 | 19 (1-268) | 19 (1-205) | 19 (1-268) |
| Median time to nadir, d (25th-75th percentile) | 36 (17-77) | 26 (14-107) | 38 (18-77) |
| Thrombocytopenia | |||
| Grade 36-151 | 75 (29) | 12 (32) | 63 (28) |
| Grade 46-151 | 85 (33) | 12 (32) | 73 (32) |
| Median duration, d (range)6-152 | 31 (1-445) | 28 (1-202) | 31 (1-445) |
| Median time to nadir, d (25th-75th percentile) | 37 (15-81) | 29 (10-71) | 39 (15-81) |
| Abnormality6-150 . | All patients (n = 260) . | 400-mg-dose group (n = 37) . | 600-mg-dose group (n = 223) . |
|---|---|---|---|
| Anemia | |||
| Grade 36-151 | 106 (41) | 16 (43) | 90 (40) |
| Grade 46-151 | 29 (11) | 6 (16) | 23 (10) |
| Neutropenia | |||
| Grade 36-151 | 41 (16) | 5 (14) | 36 (16) |
| Grade 46-151 | 124 (48) | 20 (54) | 104 (47) |
| Median duration, d (range)6-152 | 19 (1-268) | 19 (1-205) | 19 (1-268) |
| Median time to nadir, d (25th-75th percentile) | 36 (17-77) | 26 (14-107) | 38 (18-77) |
| Thrombocytopenia | |||
| Grade 36-151 | 75 (29) | 12 (32) | 63 (28) |
| Grade 46-151 | 85 (33) | 12 (32) | 73 (32) |
| Median duration, d (range)6-152 | 31 (1-445) | 28 (1-202) | 31 (1-445) |
| Median time to nadir, d (25th-75th percentile) | 37 (15-81) | 29 (10-71) | 39 (15-81) |
Values are numbers (%) of patients unless otherwise indicated.
Abnormalities occurring during treatment or worsening from baseline level to the indicated grade.
National Cancer Institute-National Institutes of Health common toxicity criteria (CTC). For CTC grade 3, the neutrophil count was 0.5 to < 1.0 × 109/L; the platelet count, 10.0 to < 50.0 × 109/L; and the hemoglobin level, < 65 to 80 g/L. For CTC grade 4; the neutrophil count was < 0.5 × 109/L; the platelet count, < 10.0 × 109/L; and the hemoglobin level, < 65 g/L.
The duration of cytopenias refers to all episodes of grade 3 or 4 abnormalities.