Table 1. Clinical characteristics of... | American Society of Hematology

Table 1.

Clinical characteristics of patients and cytokine responses

Patient	Age, y	Sex	Stage^*	BM plasma cells, %	Immunoglobulin class	Sample taken at debut	IL-6 response^†	P for IL-6 response	IL-21 response^†	P for IL-21 response
1	62	M	IIIA^‡	50	κ	Yes	593	< .01	134	< .01
2	69	F	IIIA	13	IgGκ	Yes	138	< .01	91	NS
3	52	M	IIIA	65	Nonsecretory	No	106	NS	110	NS
4	52	M	IIIA	49	IgGκ	No	893	< .01	283	< .01
5	50	M	IIIA	45	IgGκ	Yes	277	< .01	139	< .01
6	64	F	IIA	15	IgGκ	Yes	183	< .05	182	< .05
7	69	M	IIIA	17	IgGκ	Yes	78	NS	64	NS
8	68	M	IIIA	30	IgGκ	No	241	< .01	72	NS
9	81	F	IIIA	60	IgGκ	No	144	NS	93	NS

Patient	Age, y	Sex	Stage^*	BM plasma cells, %	Immunoglobulin class	Sample taken at debut	IL-6 response^†	P for IL-6 response	IL-21 response^†	P for IL-21 response
1	62	M	IIIA^‡	50	κ	Yes	593	< .01	134	< .01
2	69	F	IIIA	13	IgGκ	Yes	138	< .01	91	NS
3	52	M	IIIA	65	Nonsecretory	No	106	NS	110	NS
4	52	M	IIIA	49	IgGκ	No	893	< .01	283	< .01
5	50	M	IIIA	45	IgGκ	Yes	277	< .01	139	< .01
6	64	F	IIA	15	IgGκ	Yes	183	< .05	182	< .05
7	69	M	IIIA	17	IgGκ	Yes	78	NS	64	NS
8	68	M	IIIA	30	IgGκ	No	241	< .01	72	NS
9	81	F	IIIA	60	IgGκ	No	144	NS	93	NS

Primary cells were stimulated with IL-21 (40 ng/mL) or IL-6 (1 ng/mL).

NS indicates not statistically significant.

According to Durie and Salmon.22

†

Percentage of ³H-thymidine incorporation compared with unstimulated cells (100%). Absolute counts per minute (cpm) ranged from 13 to 256 for the unstimulated cells.

‡

Plasma cell leukemia.

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