Table 1. Comparative functional analysis... | American Society of Hematology

Table 1.

Comparative functional analysis of leukapheresis from patients mobilized with granulocyte colony-stimulating factor alone or in combination with stem cell factor

Parameter	G-CSF MPB, n = 4	G-CSF + SCF MPB, n = 4
MNCs, no.	2.6 ± 0.9 × 10¹⁰	5.9 ± 1.1 × 10¹⁰^*
Leukapheresis vol, mL	293 ± 36	240 ± 30
MNCs per mL leukapheresis product, no.	0.9 ± 0.4 × 10⁸	2.4 ± 0.2 × 10⁸^†
Frequency of CD34⁺ cells in MNCs, %	1.2 ± 0.5	4.1 ± 0.9^*
CD34⁺cells, no.	4.7 ± 2.9 × 10⁸	26.5 ± 9.7 × 10⁸
CD34⁺ per mL leukapheresis, no.	1.4 ± 0.7 × 10⁶	10.5 ± 2.9 × 10⁶^*
SRCs per MNCs collected in LDA, no.	1 in 8.2 × 10⁶	1 in 8.1 × 10⁶
MNCs, range, no.	4.3-14.8 × 10⁶^‡	4.6-14.0 × 10⁶^‡
SRCs, no.	3130 ± 936	7220 ± 1320^*
SRCs per mL leukapheresis product, no.	10.5 ± 2.7	29.7 ± 1.2^†
SRCs per 10⁶ CD34⁺ cells, no.	18.3 ± 8.8	4.8 ± 2.5

Parameter	G-CSF MPB, n = 4	G-CSF + SCF MPB, n = 4
MNCs, no.	2.6 ± 0.9 × 10¹⁰	5.9 ± 1.1 × 10¹⁰^*
Leukapheresis vol, mL	293 ± 36	240 ± 30
MNCs per mL leukapheresis product, no.	0.9 ± 0.4 × 10⁸	2.4 ± 0.2 × 10⁸^†
Frequency of CD34⁺ cells in MNCs, %	1.2 ± 0.5	4.1 ± 0.9^*
CD34⁺cells, no.	4.7 ± 2.9 × 10⁸	26.5 ± 9.7 × 10⁸
CD34⁺ per mL leukapheresis, no.	1.4 ± 0.7 × 10⁶	10.5 ± 2.9 × 10⁶^*
SRCs per MNCs collected in LDA, no.	1 in 8.2 × 10⁶	1 in 8.1 × 10⁶
MNCs, range, no.	4.3-14.8 × 10⁶^‡	4.6-14.0 × 10⁶^‡
SRCs, no.	3130 ± 936	7220 ± 1320^*
SRCs per mL leukapheresis product, no.	10.5 ± 2.7	29.7 ± 1.2^†
SRCs per 10⁶ CD34⁺ cells, no.	18.3 ± 8.8	4.8 ± 2.5

Leukapheresis product was harvested from patients with multiple myeloma after growth factor treatment. Data represent the mean cell yield ± SEM for leukapheresis product harvested from 4 individual patients for each mobilization regime.

P < .05.

†

P < .01.

‡

These data have 95% confidence.

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