Serologic response of mice vaccinated with CD20 peptide conjugates to full-length N-terminal and C-terminal halves of the immunizing peptides
| Immunogen . | Target ELISA antigen* . | |||||
|---|---|---|---|---|---|---|
| Full mouse sequence . | Mouse N . | Mouse C . | Full human sequence . | Human N . | Human C . | |
| msCD20-KLH | +++ | − | + | − | − | + |
| huCD20-KLH | + | − | − | ++ | + | ++ |
| Immunogen . | Target ELISA antigen* . | |||||
|---|---|---|---|---|---|---|
| Full mouse sequence . | Mouse N . | Mouse C . | Full human sequence . | Human N . | Human C . | |
| msCD20-KLH | +++ | − | + | − | − | + |
| huCD20-KLH | + | − | − | ++ | + | ++ |
ELISA indicates enzyme-linked immunosorbent assay; KLH, keyhole limpet hemocyanin; −, < 10% of control; +, 10%-60% of control; ++, 60%-100% of control; +++, > 100% of control.
Full mouse sequence is the immunizing peptide, mouse or human N is the N-terminal 22 amino acids of the immunizing peptide, and mouse or human C is the C-terminal 22 amino acids of the immunizing peptide.