Table 1.

Cell surface expression and cofactor function of TM mutants

TM mutantTM antigen* (% of wild-type)Significantly decreased (P)Km†Significantly increased (P)
Wild-type Reference  634 ± 6  
Ala25Thr 103 ± 9 NS 609 ± 20 NS 
Gly61Ala 100 ± 8 NS 661 ± 119 NS 
Arg385Ser 50.2 ± 5 .001 2854 ± 249 < .0001 
Asp468Tyr 97.8 ± 9 NS 733 ± 202 NS 
Pro477Ser 76.8 ± 1 .001 2716 ± 565 < .0001 
Pro483Leu 82.1 ± 8 .007 827 ± 178 .03 
TM mutantTM antigen* (% of wild-type)Significantly decreased (P)Km†Significantly increased (P)
Wild-type Reference  634 ± 6  
Ala25Thr 103 ± 9 NS 609 ± 20 NS 
Gly61Ala 100 ± 8 NS 661 ± 119 NS 
Arg385Ser 50.2 ± 5 .001 2854 ± 249 < .0001 
Asp468Tyr 97.8 ± 9 NS 733 ± 202 NS 
Pro477Ser 76.8 ± 1 .001 2716 ± 565 < .0001 
Pro483Leu 82.1 ± 8 .007 827 ± 178 .03 
*

Results expressed as mean ± SE, n = 6.

†

Results expressed in nmol/L as mean ± SE, n = 6-10.

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