Relationship between the factor XIIIA Val34Leu polymorphism and thrombotic disease
| Disease . | Association with disease . | No. subjects (controls) . | Origin of subjects . | Odds ratio . | Author . |
|---|---|---|---|---|---|
| MI | + | 398 (196) | Northern UK | 0.67 (0.54-0.85) | Kohler et al108 |
| MI | + | 470 | Finland | 0.59 (0.38-0.93) | Wartiovaara et al127 |
| MI | + | 150 (150) | Brazil | 0.6 (0.4-0.9) | Franco et al128 |
| MI | − | 201 (244) | Southern France | NA | Canavy et al131 |
| MI | − | 423 (479) | US | NA | Aleksic et al132 |
| MI | − | 191 | UK Asians | NA | Warner et al134 |
| MI | + | 120 (120) | Northern Italy | 0.59 | Gemmati et al129 |
| ICH | + | 130 (130) | Northern Italy | 1.74 | Gemmati et al129 |
| BI | + | 120 | Northern Italy | 0.60 | Gemmati et al129 |
| MI3-150 | + | 68 | US | 0.8 | Reiner et al130 |
| BI3-150 | − | 41 (345) | US | NA | Reiner et al130 |
| MI | − | 101 | Southern Spain | NA | Corral et al133 |
| DVT | − | 97 | Southern Spain | NA | Corral et al133 |
| CVD | − | 104 | Southern Spain | NA | Corral et al133 |
| DVT | + | 226 (254) | Northern UK | 0.63 (0.38-0.82) | Catto et al136 |
| DVT | + | 189 (189) | Brazil | 0.16 (0.05-0.5) for homozygous Leu | Franco et al137 |
| DVT | + | 154 (308) | Austria | 0.7 (0.5-1.0) | Renner et al138 |
| DVT | − | 273 (288) | Hungary | NA | Balogh et al114 |
| DVT | − | 427 (1045) | Southern Italy | NA | Margaglione et al139 |
| ICH | + | 612 (436) | Northern UK | — | Catto et al143 |
| BI | + | 456 (456) | France | 0.58 (0.44-0.75) | Elbaz et al145 |
| ICH | − | 201 (201) | Southern Spain | NA | Corral et al144 |
| RAO | + | 108 (313) | Austria | 0.22 for homozygous Leu | Weger et al147 |
| Disease . | Association with disease . | No. subjects (controls) . | Origin of subjects . | Odds ratio . | Author . |
|---|---|---|---|---|---|
| MI | + | 398 (196) | Northern UK | 0.67 (0.54-0.85) | Kohler et al108 |
| MI | + | 470 | Finland | 0.59 (0.38-0.93) | Wartiovaara et al127 |
| MI | + | 150 (150) | Brazil | 0.6 (0.4-0.9) | Franco et al128 |
| MI | − | 201 (244) | Southern France | NA | Canavy et al131 |
| MI | − | 423 (479) | US | NA | Aleksic et al132 |
| MI | − | 191 | UK Asians | NA | Warner et al134 |
| MI | + | 120 (120) | Northern Italy | 0.59 | Gemmati et al129 |
| ICH | + | 130 (130) | Northern Italy | 1.74 | Gemmati et al129 |
| BI | + | 120 | Northern Italy | 0.60 | Gemmati et al129 |
| MI3-150 | + | 68 | US | 0.8 | Reiner et al130 |
| BI3-150 | − | 41 (345) | US | NA | Reiner et al130 |
| MI | − | 101 | Southern Spain | NA | Corral et al133 |
| DVT | − | 97 | Southern Spain | NA | Corral et al133 |
| CVD | − | 104 | Southern Spain | NA | Corral et al133 |
| DVT | + | 226 (254) | Northern UK | 0.63 (0.38-0.82) | Catto et al136 |
| DVT | + | 189 (189) | Brazil | 0.16 (0.05-0.5) for homozygous Leu | Franco et al137 |
| DVT | + | 154 (308) | Austria | 0.7 (0.5-1.0) | Renner et al138 |
| DVT | − | 273 (288) | Hungary | NA | Balogh et al114 |
| DVT | − | 427 (1045) | Southern Italy | NA | Margaglione et al139 |
| ICH | + | 612 (436) | Northern UK | — | Catto et al143 |
| BI | + | 456 (456) | France | 0.58 (0.44-0.75) | Elbaz et al145 |
| ICH | − | 201 (201) | Southern Spain | NA | Corral et al144 |
| RAO | + | 108 (313) | Austria | 0.22 for homozygous Leu | Weger et al147 |
MI indicates myocardial infarction; ICH, intracranial hemorrhage; BI, brain infarction; TIA, transient ischemic attack, DVT, deep vein thrombosis; CVD, cerebrovascular disease; RAO, retinal artery occlusion; and NA, not applicable.
Subjects were all young women.