Patient characteristics
| Patient . | Age at diagnosis, y . | Phase at diagnosis . | Splenomegaly . | WBC count at diagnosis, × 109/L . | Differential count at diagnosis . | Platelet count at diagnosis, × 109/L . | Maximal monocyte count, × 109/L (%) . | Therapy prior to imatinib . | Best response prior to imatinib . | Duration of chronic phase prior to imatinib, mo . | Cytogenetics at initiating imatinib . | Best response to imatinib . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case #1 (male) | 41 | Chronic | Yes | 189.5 | 60% mature neutrophils, 32% immature neutrophils, 2% blasts, 4% eosinophils, 2% lymphocytes | 184 | 11 (13) | IFN-alpha (9 MU/d) + hydrea | Complete hematologic response | 56 | 100% Ph-positive | Complete cytogenetic remission |
| Case #2 (female) | 64 | Chronic | No | 53.2 | 72% mature neutrophils, 22% immature neutrophils, 1% blasts, 3% lymphocytes, 2% monocytes | 156 | 3.6 (27) | IFN-alpha (3-12.5 MU/wk) + hydrea | Major cytogenetic response (1/16 metaphases Ph-positive) | 62 | 50% Ph-positive | Complete cytogenetic remission |
| Case reported by Roman et al6 | 75 | Chronic | No | 18.5 | 76% mature neutrophils, 1% basophils, 17% lymphocytes, 6% monocytes | 257 | 1.1 (6) (at diagnosis) | NA | NA | 66 (at last reporting) | NA | NA |
| Patient . | Age at diagnosis, y . | Phase at diagnosis . | Splenomegaly . | WBC count at diagnosis, × 109/L . | Differential count at diagnosis . | Platelet count at diagnosis, × 109/L . | Maximal monocyte count, × 109/L (%) . | Therapy prior to imatinib . | Best response prior to imatinib . | Duration of chronic phase prior to imatinib, mo . | Cytogenetics at initiating imatinib . | Best response to imatinib . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case #1 (male) | 41 | Chronic | Yes | 189.5 | 60% mature neutrophils, 32% immature neutrophils, 2% blasts, 4% eosinophils, 2% lymphocytes | 184 | 11 (13) | IFN-alpha (9 MU/d) + hydrea | Complete hematologic response | 56 | 100% Ph-positive | Complete cytogenetic remission |
| Case #2 (female) | 64 | Chronic | No | 53.2 | 72% mature neutrophils, 22% immature neutrophils, 1% blasts, 3% lymphocytes, 2% monocytes | 156 | 3.6 (27) | IFN-alpha (3-12.5 MU/wk) + hydrea | Major cytogenetic response (1/16 metaphases Ph-positive) | 62 | 50% Ph-positive | Complete cytogenetic remission |
| Case reported by Roman et al6 | 75 | Chronic | No | 18.5 | 76% mature neutrophils, 1% basophils, 17% lymphocytes, 6% monocytes | 257 | 1.1 (6) (at diagnosis) | NA | NA | 66 (at last reporting) | NA | NA |
WBC indicates white blood cell; NA, not applicable.