Gene status, expression, and chromosome studies in 28 children with T-ALL
| Patient . | HOX11L2 . | HOX11 . | LYL1 . | LMO2 . | TAL1 . | SIL-TAL1 . | CDKN2A/ CDKN2D . | Karyotype . |
|---|---|---|---|---|---|---|---|---|
| UPNT1 | 10 520 | — | ND | ND | ND | − | ND | 46,XY[11] |
| UPNT1 relapse | 13 120 | — | 112 000 | 64 366 | 136 084 | − | ND | ND |
| UPNT2 | 9 306 | — | ND | ND | ND | − | −/− | 46,XX[18] |
| UPNT3 | — | — | 64 653 | 18 692 | 5 276 | − | ± | 46,XY,t(10;11)(p14;q14)[10]/92,idemx2,i(17)(q10)x2[13]/46,XY[1] |
| UPNT4 | — | — | 23 603 | 20 407 | 47 845 | + | −/− | 46,XY[12] |
| UPNT5 | — | 8 | 11 360 | 19 775 | 14 852 | + | +/+ | Failure |
| UPNT6 | — | 2 490 | 27 637 | 14 068 | 34 184 | − | ND | Failure |
| UPNT7 | — | — | 43 521 | 30 139 | 3 500 | − | +/+ | 45,XX,t(4;7)(p15-16;q11),-17[6]/46,XX[19] |
| UPNT8 | 8 580 | — | 22 463 | 1 329 | 8 620 | − | −/− | 46,XX,add(5q34)[3]/idem,del(9p21-22)[2]/46,XX[8] |
| UPNT8 relapse | 11 549 | — | ND | ND | ND | − | −/− | ND |
| UPNT9 | — | — | 3 581 | 743 | 6 447 | + | −/− | 47,XX,del(6q),t(8;14)(q24;q11),+ 20[18]/46,XX[8] |
| UPNT10 | — | — | 3 540 | 1 429 | 8 675 | − | ± | Failure |
| UPNT11 | 6 950 | — | 3 541 | 132 | 66 | − | +/+ | 46,XY[18] |
| UPNT12 | — | — | 26 103 | 19 299 | 332 | − | −/− | 46,XY[14] |
| UPNT13 | — | — | 1 850 | 1 211 | 23 115 | + | −/− | 46,XX,add(13)(p13)[18]/46,XX[32] |
| UPNT14 | — | — | 34 467 | 35 276 | 11 504 | − | ND | 46,XX,add(1)(q?32),add(5)(p?13),-7,add(10)(p13-14),+ mar[25]/ 46,XX[5] |
| UPNT15 | — | — | 22 308 | 2 975 | 4 659 | − | ± | Failure |
| UPNT16 | — | — | 6 815 | 310 | 66 377 | − | −/− | Failure |
| UPNT17 | — | — | 7 797 | 6 067 | 761 | − | +/+ | 46,XX[24] |
| UPNT18 | 21 680 | — | 13 326 | 364 | 86 | − | −/− | Failure |
| UPNT19 | — | — | 8 864 | 2 224 | 1 932 | − | ± | 46,XY[26] |
| UPNT20 | — | — | 13 590 | 8 204 | 2 208 | − | +/+ | 46,XY[22] |
| UPNT21 | — | — | 59 218 | 13 397 | 319 | − | −/− | 46,XY[17] |
| UPNT22 | — | — | 4 678 | 1 828 | 580 | − | ND | 46,XX[24] |
| UPNT23 | — | — | ND | ND | ND | + | −/− | 46,XY,del(9)(p21)[2] |
| UPNT24 | 3 984 | — | 7 895 | 2 251 | 717 | − | −/− | 46,XY[27] |
| UPNT25 | — | — | 1 333 | 1 022 | 1 124 | − | −/− | 46,XY,inv?del(2)[22] |
| UPNT26 | — | — | 38 824 | 15 456 | 14 965 | − | ± | Failure |
| UPNT27 | — | 34 388 | 19 939 | 321 | 78 | − | −/− | 46,XX,add(22)(q13)[4]/46,XX[28] |
| UPNT28 | — | — | 1 155 | 2 073 | 3 956 | + | +/+ | 46,XY[26] |
| Thymus | — | — | 250 | 191 | 436 | — | — | — |
| Bone marrow | — | — | 10 792 | 13 202 | 27 197 | — | — | —— |
| Patient . | HOX11L2 . | HOX11 . | LYL1 . | LMO2 . | TAL1 . | SIL-TAL1 . | CDKN2A/ CDKN2D . | Karyotype . |
|---|---|---|---|---|---|---|---|---|
| UPNT1 | 10 520 | — | ND | ND | ND | − | ND | 46,XY[11] |
| UPNT1 relapse | 13 120 | — | 112 000 | 64 366 | 136 084 | − | ND | ND |
| UPNT2 | 9 306 | — | ND | ND | ND | − | −/− | 46,XX[18] |
| UPNT3 | — | — | 64 653 | 18 692 | 5 276 | − | ± | 46,XY,t(10;11)(p14;q14)[10]/92,idemx2,i(17)(q10)x2[13]/46,XY[1] |
| UPNT4 | — | — | 23 603 | 20 407 | 47 845 | + | −/− | 46,XY[12] |
| UPNT5 | — | 8 | 11 360 | 19 775 | 14 852 | + | +/+ | Failure |
| UPNT6 | — | 2 490 | 27 637 | 14 068 | 34 184 | − | ND | Failure |
| UPNT7 | — | — | 43 521 | 30 139 | 3 500 | − | +/+ | 45,XX,t(4;7)(p15-16;q11),-17[6]/46,XX[19] |
| UPNT8 | 8 580 | — | 22 463 | 1 329 | 8 620 | − | −/− | 46,XX,add(5q34)[3]/idem,del(9p21-22)[2]/46,XX[8] |
| UPNT8 relapse | 11 549 | — | ND | ND | ND | − | −/− | ND |
| UPNT9 | — | — | 3 581 | 743 | 6 447 | + | −/− | 47,XX,del(6q),t(8;14)(q24;q11),+ 20[18]/46,XX[8] |
| UPNT10 | — | — | 3 540 | 1 429 | 8 675 | − | ± | Failure |
| UPNT11 | 6 950 | — | 3 541 | 132 | 66 | − | +/+ | 46,XY[18] |
| UPNT12 | — | — | 26 103 | 19 299 | 332 | − | −/− | 46,XY[14] |
| UPNT13 | — | — | 1 850 | 1 211 | 23 115 | + | −/− | 46,XX,add(13)(p13)[18]/46,XX[32] |
| UPNT14 | — | — | 34 467 | 35 276 | 11 504 | − | ND | 46,XX,add(1)(q?32),add(5)(p?13),-7,add(10)(p13-14),+ mar[25]/ 46,XX[5] |
| UPNT15 | — | — | 22 308 | 2 975 | 4 659 | − | ± | Failure |
| UPNT16 | — | — | 6 815 | 310 | 66 377 | − | −/− | Failure |
| UPNT17 | — | — | 7 797 | 6 067 | 761 | − | +/+ | 46,XX[24] |
| UPNT18 | 21 680 | — | 13 326 | 364 | 86 | − | −/− | Failure |
| UPNT19 | — | — | 8 864 | 2 224 | 1 932 | − | ± | 46,XY[26] |
| UPNT20 | — | — | 13 590 | 8 204 | 2 208 | − | +/+ | 46,XY[22] |
| UPNT21 | — | — | 59 218 | 13 397 | 319 | − | −/− | 46,XY[17] |
| UPNT22 | — | — | 4 678 | 1 828 | 580 | − | ND | 46,XX[24] |
| UPNT23 | — | — | ND | ND | ND | + | −/− | 46,XY,del(9)(p21)[2] |
| UPNT24 | 3 984 | — | 7 895 | 2 251 | 717 | − | −/− | 46,XY[27] |
| UPNT25 | — | — | 1 333 | 1 022 | 1 124 | − | −/− | 46,XY,inv?del(2)[22] |
| UPNT26 | — | — | 38 824 | 15 456 | 14 965 | − | ± | Failure |
| UPNT27 | — | 34 388 | 19 939 | 321 | 78 | − | −/− | 46,XX,add(22)(q13)[4]/46,XX[28] |
| UPNT28 | — | — | 1 155 | 2 073 | 3 956 | + | +/+ | 46,XY[26] |
| Thymus | — | — | 250 | 191 | 436 | — | — | — |
| Bone marrow | — | — | 10 792 | 13 202 | 27 197 | — | — | —— |
HOX11 and HOX11L2 normalized copy numbers are indicated in positive samples.
+ indicates presence of the SIL-TAL1 fusion or 1 copy of the CDKN2A/CDKN2D locus; −, absence of theSIL-TAL1 fusion or 1 CDKN2A/CDKN2Dlocus; ND, not done.
Copy numbers of samples considered positive for LYL1,TAL1, and LMO2 are in bold numbers.
Thymus and bone marrow expression level is the mean of 5 normal samples.