Outcome following unrelated donor BMT for SAA: univariate analysis
| Covariates . | Graft failure, % . | P . | Grade III/IV acute GVHD, % . | P . | Chronic GVHD, % . | P . | 5-year survival, % . | P . |
|---|---|---|---|---|---|---|---|---|
| Conditioning regimen | ||||||||
| TBI + CY + ATG | 2 | 10 | 22 | 75 | ||||
| LFI + CY + ATG | 25 | 15 | 23 | 61 | ||||
| TBI + CY | 13 | 29 | 34 | 53 | ||||
| LFI + CY | 21 | .02 | 18 | .09 | 35 | .50 | 24 | .10 |
| HLA matching by DNA typing | ||||||||
| HLA-A, -B, -DRB1 matched | 8 | 12 | 26 | 60 | ||||
| A locus mismatched | 24 | 22 | 13 | 46 | ||||
| B locus mismatched | 11 | 30 | 29 | 32 | ||||
| DRB1 locus mismatched | 14 | 29 | 39 | 71 | ||||
| 2 or more loci mismatched | 20 | .42 | 27 | .25 | 67 | .28 | 30 | .009 |
| Covariates . | Graft failure, % . | P . | Grade III/IV acute GVHD, % . | P . | Chronic GVHD, % . | P . | 5-year survival, % . | P . |
|---|---|---|---|---|---|---|---|---|
| Conditioning regimen | ||||||||
| TBI + CY + ATG | 2 | 10 | 22 | 75 | ||||
| LFI + CY + ATG | 25 | 15 | 23 | 61 | ||||
| TBI + CY | 13 | 29 | 34 | 53 | ||||
| LFI + CY | 21 | .02 | 18 | .09 | 35 | .50 | 24 | .10 |
| HLA matching by DNA typing | ||||||||
| HLA-A, -B, -DRB1 matched | 8 | 12 | 26 | 60 | ||||
| A locus mismatched | 24 | 22 | 13 | 46 | ||||
| B locus mismatched | 11 | 30 | 29 | 32 | ||||
| DRB1 locus mismatched | 14 | 29 | 39 | 71 | ||||
| 2 or more loci mismatched | 20 | .42 | 27 | .25 | 67 | .28 | 30 | .009 |