Table 3. Summary of hematologic, bone... | American Society of Hematology

Table 3.

Summary of hematologic, bone marrow morphologic, and cytogenetic responses to imatinib mesylate in 19 chronic-phase chronic myelogenous leukemia patients

Patient no.	Initial dose imatinib mesylate (mg/day)	Time to CHR, mo	Time to marrow morphologic remission, mo	Hematologic status at 14 mo	Best cytogenetic response	Ph+ metaphases at best response, % (time observed, mo)	Ph+ metaphases at 14 mo, %
1	400	2	5	CHR	Complete	0 (5)	0
2	600	2	2	CHR	Complete	0 (5)	0
3	600	2	2	CHR	Complete	0 (8)	0
4	400	2	5	CHR	Complete	0 (8)	0
5	600	2	2	CHR	Complete	0 (8)	0
6	600	2	2	CHR	Complete	0 (5)	0
7	300	2	8	CHR	Absent	100	100
8	400	2	5	CHR	Absent	67	100
9	350	2	5	CHR	Absent	100	100
10	500	2	5	CHR	Absent	95	No growth
11	500	2	8	CHR	Absent	93	93
12	500	2	5	CHR	Absent	90	90
13	400	11	5	CHR	Absent	100	100
14	300	2	8	Relapse of CML	Partial	20 (2)	40
15	350	5	8	CHR	Partial	8 (11)	30
16	300	2	5	CHR	Partial	5 (14)	5
17	350	2	5	CHR	Partial	25 (8)	35
18	400	2	5	CHR	Partial	5 (8)	55
19	500	2	2	CHR	Partial	5 (11)	15

Patient no.	Initial dose imatinib mesylate (mg/day)	Time to CHR, mo	Time to marrow morphologic remission, mo	Hematologic status at 14 mo	Best cytogenetic response	Ph+ metaphases at best response, % (time observed, mo)	Ph+ metaphases at 14 mo, %
1	400	2	5	CHR	Complete	0 (5)	0
2	600	2	2	CHR	Complete	0 (5)	0
3	600	2	2	CHR	Complete	0 (8)	0
4	400	2	5	CHR	Complete	0 (8)	0
5	600	2	2	CHR	Complete	0 (8)	0
6	600	2	2	CHR	Complete	0 (5)	0
7	300	2	8	CHR	Absent	100	100
8	400	2	5	CHR	Absent	67	100
9	350	2	5	CHR	Absent	100	100
10	500	2	5	CHR	Absent	95	No growth
11	500	2	8	CHR	Absent	93	93
12	500	2	5	CHR	Absent	90	90
13	400	11	5	CHR	Absent	100	100
14	300	2	8	Relapse of CML	Partial	20 (2)	40
15	350	5	8	CHR	Partial	8 (11)	30
16	300	2	5	CHR	Partial	5 (14)	5
17	350	2	5	CHR	Partial	25 (8)	35
18	400	2	5	CHR	Partial	5 (8)	55
19	500	2	2	CHR	Partial	5 (11)	15

CHR indicates complete hematologic response; Ph+, Philadelphia chromosome-positive metaphases.

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