Histopathologic lesions in transplanted mice
| Organ . | 3.5 weeks AT . | 6-9 weeks AT . | TβRII +/− . | ||
|---|---|---|---|---|---|
| TβRII −/− . | S . | TβRII −/− . | S . | ||
| Stomach | 1 (6) | + | 8 (8) | ++++ | 0 (4) |
| Pancreas | 1 (6) | + | 8 (8) | ++++ | 0 (5) |
| Spleen | 0 (7) | 8 (8) | +++ | 0 (4) | |
| Lung | 1 (8) | + | 7 (7) | +++ | 0 (4) |
| Thymus | ND | 3 (4) | ++++ | 0 (4) | |
| Liver | 0 (8) | 6 (9) | ++ | 0 (5) | |
| Colon | 0 (8) | 6 (9) | ++ | 0 (5) | |
| Small intestines | 0 (8) | 2 (9) | ++ | 0 (5) | |
| Kidney | 0 (8) | 1 (9) | ++ | 0 (5) | |
| Heart | 0 (8) | 0 (9) | 0 (4) | ||
| Esophagus | 0 (7) | 0 (6) | 0 (3) | ||
| Organ . | 3.5 weeks AT . | 6-9 weeks AT . | TβRII +/− . | ||
|---|---|---|---|---|---|
| TβRII −/− . | S . | TβRII −/− . | S . | ||
| Stomach | 1 (6) | + | 8 (8) | ++++ | 0 (4) |
| Pancreas | 1 (6) | + | 8 (8) | ++++ | 0 (5) |
| Spleen | 0 (7) | 8 (8) | +++ | 0 (4) | |
| Lung | 1 (8) | + | 7 (7) | +++ | 0 (4) |
| Thymus | ND | 3 (4) | ++++ | 0 (4) | |
| Liver | 0 (8) | 6 (9) | ++ | 0 (5) | |
| Colon | 0 (8) | 6 (9) | ++ | 0 (5) | |
| Small intestines | 0 (8) | 2 (9) | ++ | 0 (5) | |
| Kidney | 0 (8) | 1 (9) | ++ | 0 (5) | |
| Heart | 0 (8) | 0 (9) | 0 (4) | ||
| Esophagus | 0 (7) | 0 (6) | 0 (3) | ||
The number of mice with lesions in the specified organs are shown and the total number of animals examined are indicated within parentheses. The genotype refers to the donor bone marrow following polyI:polyC induction. S denotes the most frequent subjective estimate of severity, where + indicates mild, ++ indicates moderate, +++ indicates pronounced, and ++++ indicates very severe. AT indicates after transplantation.