Human TFs identified by homology with murine TFs
| Mouse gene . | Mouse gene description . | Human UniGene cluster ID . | Human gene . | Human gene description . | Band . | FB . | Abundance . | Characterization . |
|---|---|---|---|---|---|---|---|---|
| Nrf-1 | Activator involved in nuclear-mitochondrial interactions | Hs.180069 | NRF1 | Nuclear respiratory factor 1 | 7q32 | 425.8 | VH | W |
| Dnmt-3b | De novo cytosine methyltransferase found in ES cells | Hs.251673 | DNMT3B | DNA (cytosine-5-)methyltransferase 3 β | 20q11.2 | 336.2 | VH | W |
| IFP-35 | Associates with B-ATF | Hs.50842 | IFI35 | Interferon-induced protein 35 | 17q21 | 191.4 | VH | PC |
| LL2in13291 | Homolog of KIAA0326; contains 19 C2H2 zinc fingers | Hs.301094 | KIAA0326 | KIAA0326 protein | N/A | 126.4 | VH | N |
| Sox-13 | SRY related; contains HMG box | Hs.201671 | SOX13 | SRY (sex determining region Y)-box 13 | 1q32 | 73.3 | H | PC |
| SKIP | Interacts with Ski, which may arrest hematopoietic differentiation | Hs.79008 | SNW1 | SKI-INTERACTING PROTEIN | 14q21.1-q24.3 | 40.6 | H | W |
| HPI-BP74/hetero-chromatinic | Binds to TIF1 | Hs.142442 | HP1-BP74 | HP1-BP74 | 1pter-p36.13 | 39.1 | H | N |
| LL2in10006 | Helicase and SNF2 domains; novel helicase | Hs.16933 | HARP | HepA-related protein | 2q34-q35 | 28.6 | H | W |
| Stat-5a | Possible role in regulation of endothelial function | Hs.181112 | HSPC126 | HSPC126 protein | 13q12.2-q13.3 | 25.4 | H | PC |
| CtBP2 | Potent repressor; interacts with Evi-1, AREB6, ZEB, and FOG | Hs.171391 | CTBP2 | C-terminal binding protein 2 | 21q21.3 | 22.2 | I | W |
| HMG-1 | Unwinds double-stranded DNA | Hs.274472 | HMG1 | High-mobility group (nonhistone chromosomal) protein 1 | 13q12 | 18.1 | I | W |
| HMG-17 | Alters interaction between DNA and the histone octamer, maintaining chromatin conformation | Hs.181163 | HMG17 | High-mobility group (nonhistone chromosomal) protein 17 | 1p36.1 | 17.9 | I | W |
| LD5-1 | Heterochromatosis locus | Hs.279586 | LOC51578 | Adrenal gland protein AD-004 | 5 | 17.0 | I | N |
| Heterochromatin protein p25 | Regulated during cell cycle | Hs.77254 | CBX1 | Chromobox homolog 1 (Drosophila HP1 β) | 17q | 16.5 | I | PC |
| Dnmt-3a | De novo cytosine methyltransferase found in ES cells | Hs.241565 | DNMT3A | DNA (cytosine-5-)methyltransferase 3 α | 2p23 | 15.0 | I | W |
| SAP1a | Ets family; implicated in serum response of fos promoter | Hs.169241 | ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | 1q32 | 12.4 | I | W |
| Rpt-1r | Down-regulates interleukin 2 receptor | Hs.125300 | RNF21 | Ring finger protein 21, interferon responsive | 11p15 | 11.7 | I | PC |
| Histone H3.3A | Nucleosomal histone | Hs.181307 | H3F3A | H3 histone, family 3A | 1q41 | 11.3 | I | W |
| HCNGP | Probably involved in regulation of β2-microglobulin genes | Hs.27299 | HCNGP | Transcriptional regulator protein | 17 | 9.8 | L | N |
| HLF | bZip; fusion to E2A results in B-lineage leukemia; related to DBP | Hs.250692 | HLF | Hepatic leukemia factor | 17q22 | 8.7 | L | W |
| WBSCR11 | Chr 11, Williams-Beuren syndrome region; TFII-I domain | Hs.21075 | GTF2IRD1 | GTF2I repeat domain-containing 1 | 7q11.23 | 8.5 | L | W |
| P300/CBP cointegrator | Competes against TGIF to promote TGF-β–dependent transcriptional activation | Hs.225977 | NCOA3 | Nuclear receptor coactivator 3 | 20q12 | 8.2 | L | W |
| TIP60 | Acetylates histones to regulate X-chromosome dosage compensation | Hs.6394 | HTATIP | HIV-1 Tat interactive protein, 60 kd | 11 | 8.2 | L | W |
| CGGBP | Can bind the CGG trinucleotide; may affect FMR-1 promoter activity | Hs.86041 | CGGBP1 | CGG triplet repeat binding protein 1 | 3p12-p11.1 | 7.2 | L | PC |
| XE169 | Similar to jumonji. ARID motif, 2 PHD fingers | Hs.283429 | SMCX | SMC (mouse) homolog, X chromosome | Xp11.22-p11.21 | 6.6 | L | W |
| CPBP? | Core promoter element bp? 3 C2H2 zinc fingers | Hs.285313 | COPEB | Core promoter element binding protein | 10p15 | 6.5 | L | W |
| LL2in10261 | 7 C2H2 zinc fingers | Hs.278569 | SNX17 | Sorting nexin 17 | 2p23-p22 | 6.1 | L | N |
| SB1.8/DXS423E | Chromosome segregation protein | Hs.211602 | SMC1L1 | SMC1 (structural maintenance of chromosomes 1, yeast)-like 1 | Xp11.22-p11.21 | 6.0 | L | PC |
| HD1 | Histone deacetylase; binds to TGIF in a complex that represses TGF-β | Hs.88556 | HDAC1 | Histone deacetylase 1 | 1p34 | 5.9 | L | W |
| Erm | Ets related | Hs.43697 | ETV5 | Ets variant gene 5 (ets-related molecule) | 3q28 | 5.8 | L | W |
| Ring-box protein-1 | Component of VHL tumor suppressor complex and SCF ubiquitin ligase | Hs.279919 | RBX1 | Ring-box 1 | 22q13.2 | 5.6 | L | PC |
| SPOP | Speckle-type nuclear protein. BTB, Poz domains | Hs.129951 | SPOP | Speckle-type POZ protein | 17 | 5.5 | L | PC |
| NAB-1 | Repressor of Krox20; May repress proliferation, differentiation | Hs.107474 | NAB1 | NGFI-A binding protein 1 (ERG1 binding protein 1) | 2q32.3-q33 | 5.4 | L | W |
| Prox1 | Homeobox transcription factor required for lymphatic development | Hs.110803 | LOC51637 | CGI-99 protein | 14q13.1-q13.3 | 5.4 | L | N |
| Nmi | Interacts with myc, max, and fos | Hs.54483 | NMI | N-myc (and STAT) interactor | 2p24.3-q21.3 | 4.5 | L | W |
| TAK1/TR4 | Orphan nuclear receptor; contains C4 zinc finger | Hs.520 | NR2C2 | Nuclear receptor subfamily 2, group C, member 2 | 3p25 | 4.2 | L | W |
| LL2in14617 | Homologous human uncharacterized protein USF1 contains HLH signature | Hs.238954 | ESTs, weakly similar to KIAA1204 protein [H sapiens] | N/A | 4.2 | L | W | |
| LL2in10596 | KIAA0244; contains TFIIS and PHD motifs | Hs.78893 | KIAA0244 | KIAA0244 protein | 6q12 | 3.8 | L | N |
| Pilot/EGR-3 | Zinc finger protein | Hs.74088 | EGR3 | Early growth response 3 | 8p23-p21 | 3.8 | L | W |
| CHD-1 | Contains chromodomain | Hs.22670 | CHD1 | Chromodomain helicase DNA binding protein 1 | 5q15-q21 | 3.7 | L | W |
| HUNKI | Contains 2 bromo domains | Hs.278675 | BRD4 | Bromodomain-containing 4 | 19p13.1 | 3.7 | L | PC |
| LL1-46 | KIAA0518; HLH domain | Hs.23763 | MGA | Max-interacting protein | 15q15 | 3.4 | L | N |
| Nrf-2 | A relative of kelch suppresses nrf-2 function | Hs.155396 | NFE2L2 | Nuclear factor (erythroid-derived 2)–like 2 | 2q31 | 3.4 | L | W |
| Homeodomain-interact. pk 2 | Phosphorylates homeodomain transcription factors | Hs.236131 | HIPK2 | Homeodomain-interacting protein kinase 2 | 7q32-q34 | 3.3 | L | PC |
| SWI-SNF(60-kd subunit) | Opposes chromatin-dependent repression of transcription | Hs.79335 | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 12q13-q14 | 3.2 | L | PC |
| Mouse gene . | Mouse gene description . | Human UniGene cluster ID . | Human gene . | Human gene description . | Band . | FB . | Abundance . | Characterization . |
|---|---|---|---|---|---|---|---|---|
| Nrf-1 | Activator involved in nuclear-mitochondrial interactions | Hs.180069 | NRF1 | Nuclear respiratory factor 1 | 7q32 | 425.8 | VH | W |
| Dnmt-3b | De novo cytosine methyltransferase found in ES cells | Hs.251673 | DNMT3B | DNA (cytosine-5-)methyltransferase 3 β | 20q11.2 | 336.2 | VH | W |
| IFP-35 | Associates with B-ATF | Hs.50842 | IFI35 | Interferon-induced protein 35 | 17q21 | 191.4 | VH | PC |
| LL2in13291 | Homolog of KIAA0326; contains 19 C2H2 zinc fingers | Hs.301094 | KIAA0326 | KIAA0326 protein | N/A | 126.4 | VH | N |
| Sox-13 | SRY related; contains HMG box | Hs.201671 | SOX13 | SRY (sex determining region Y)-box 13 | 1q32 | 73.3 | H | PC |
| SKIP | Interacts with Ski, which may arrest hematopoietic differentiation | Hs.79008 | SNW1 | SKI-INTERACTING PROTEIN | 14q21.1-q24.3 | 40.6 | H | W |
| HPI-BP74/hetero-chromatinic | Binds to TIF1 | Hs.142442 | HP1-BP74 | HP1-BP74 | 1pter-p36.13 | 39.1 | H | N |
| LL2in10006 | Helicase and SNF2 domains; novel helicase | Hs.16933 | HARP | HepA-related protein | 2q34-q35 | 28.6 | H | W |
| Stat-5a | Possible role in regulation of endothelial function | Hs.181112 | HSPC126 | HSPC126 protein | 13q12.2-q13.3 | 25.4 | H | PC |
| CtBP2 | Potent repressor; interacts with Evi-1, AREB6, ZEB, and FOG | Hs.171391 | CTBP2 | C-terminal binding protein 2 | 21q21.3 | 22.2 | I | W |
| HMG-1 | Unwinds double-stranded DNA | Hs.274472 | HMG1 | High-mobility group (nonhistone chromosomal) protein 1 | 13q12 | 18.1 | I | W |
| HMG-17 | Alters interaction between DNA and the histone octamer, maintaining chromatin conformation | Hs.181163 | HMG17 | High-mobility group (nonhistone chromosomal) protein 17 | 1p36.1 | 17.9 | I | W |
| LD5-1 | Heterochromatosis locus | Hs.279586 | LOC51578 | Adrenal gland protein AD-004 | 5 | 17.0 | I | N |
| Heterochromatin protein p25 | Regulated during cell cycle | Hs.77254 | CBX1 | Chromobox homolog 1 (Drosophila HP1 β) | 17q | 16.5 | I | PC |
| Dnmt-3a | De novo cytosine methyltransferase found in ES cells | Hs.241565 | DNMT3A | DNA (cytosine-5-)methyltransferase 3 α | 2p23 | 15.0 | I | W |
| SAP1a | Ets family; implicated in serum response of fos promoter | Hs.169241 | ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | 1q32 | 12.4 | I | W |
| Rpt-1r | Down-regulates interleukin 2 receptor | Hs.125300 | RNF21 | Ring finger protein 21, interferon responsive | 11p15 | 11.7 | I | PC |
| Histone H3.3A | Nucleosomal histone | Hs.181307 | H3F3A | H3 histone, family 3A | 1q41 | 11.3 | I | W |
| HCNGP | Probably involved in regulation of β2-microglobulin genes | Hs.27299 | HCNGP | Transcriptional regulator protein | 17 | 9.8 | L | N |
| HLF | bZip; fusion to E2A results in B-lineage leukemia; related to DBP | Hs.250692 | HLF | Hepatic leukemia factor | 17q22 | 8.7 | L | W |
| WBSCR11 | Chr 11, Williams-Beuren syndrome region; TFII-I domain | Hs.21075 | GTF2IRD1 | GTF2I repeat domain-containing 1 | 7q11.23 | 8.5 | L | W |
| P300/CBP cointegrator | Competes against TGIF to promote TGF-β–dependent transcriptional activation | Hs.225977 | NCOA3 | Nuclear receptor coactivator 3 | 20q12 | 8.2 | L | W |
| TIP60 | Acetylates histones to regulate X-chromosome dosage compensation | Hs.6394 | HTATIP | HIV-1 Tat interactive protein, 60 kd | 11 | 8.2 | L | W |
| CGGBP | Can bind the CGG trinucleotide; may affect FMR-1 promoter activity | Hs.86041 | CGGBP1 | CGG triplet repeat binding protein 1 | 3p12-p11.1 | 7.2 | L | PC |
| XE169 | Similar to jumonji. ARID motif, 2 PHD fingers | Hs.283429 | SMCX | SMC (mouse) homolog, X chromosome | Xp11.22-p11.21 | 6.6 | L | W |
| CPBP? | Core promoter element bp? 3 C2H2 zinc fingers | Hs.285313 | COPEB | Core promoter element binding protein | 10p15 | 6.5 | L | W |
| LL2in10261 | 7 C2H2 zinc fingers | Hs.278569 | SNX17 | Sorting nexin 17 | 2p23-p22 | 6.1 | L | N |
| SB1.8/DXS423E | Chromosome segregation protein | Hs.211602 | SMC1L1 | SMC1 (structural maintenance of chromosomes 1, yeast)-like 1 | Xp11.22-p11.21 | 6.0 | L | PC |
| HD1 | Histone deacetylase; binds to TGIF in a complex that represses TGF-β | Hs.88556 | HDAC1 | Histone deacetylase 1 | 1p34 | 5.9 | L | W |
| Erm | Ets related | Hs.43697 | ETV5 | Ets variant gene 5 (ets-related molecule) | 3q28 | 5.8 | L | W |
| Ring-box protein-1 | Component of VHL tumor suppressor complex and SCF ubiquitin ligase | Hs.279919 | RBX1 | Ring-box 1 | 22q13.2 | 5.6 | L | PC |
| SPOP | Speckle-type nuclear protein. BTB, Poz domains | Hs.129951 | SPOP | Speckle-type POZ protein | 17 | 5.5 | L | PC |
| NAB-1 | Repressor of Krox20; May repress proliferation, differentiation | Hs.107474 | NAB1 | NGFI-A binding protein 1 (ERG1 binding protein 1) | 2q32.3-q33 | 5.4 | L | W |
| Prox1 | Homeobox transcription factor required for lymphatic development | Hs.110803 | LOC51637 | CGI-99 protein | 14q13.1-q13.3 | 5.4 | L | N |
| Nmi | Interacts with myc, max, and fos | Hs.54483 | NMI | N-myc (and STAT) interactor | 2p24.3-q21.3 | 4.5 | L | W |
| TAK1/TR4 | Orphan nuclear receptor; contains C4 zinc finger | Hs.520 | NR2C2 | Nuclear receptor subfamily 2, group C, member 2 | 3p25 | 4.2 | L | W |
| LL2in14617 | Homologous human uncharacterized protein USF1 contains HLH signature | Hs.238954 | ESTs, weakly similar to KIAA1204 protein [H sapiens] | N/A | 4.2 | L | W | |
| LL2in10596 | KIAA0244; contains TFIIS and PHD motifs | Hs.78893 | KIAA0244 | KIAA0244 protein | 6q12 | 3.8 | L | N |
| Pilot/EGR-3 | Zinc finger protein | Hs.74088 | EGR3 | Early growth response 3 | 8p23-p21 | 3.8 | L | W |
| CHD-1 | Contains chromodomain | Hs.22670 | CHD1 | Chromodomain helicase DNA binding protein 1 | 5q15-q21 | 3.7 | L | W |
| HUNKI | Contains 2 bromo domains | Hs.278675 | BRD4 | Bromodomain-containing 4 | 19p13.1 | 3.7 | L | PC |
| LL1-46 | KIAA0518; HLH domain | Hs.23763 | MGA | Max-interacting protein | 15q15 | 3.4 | L | N |
| Nrf-2 | A relative of kelch suppresses nrf-2 function | Hs.155396 | NFE2L2 | Nuclear factor (erythroid-derived 2)–like 2 | 2q31 | 3.4 | L | W |
| Homeodomain-interact. pk 2 | Phosphorylates homeodomain transcription factors | Hs.236131 | HIPK2 | Homeodomain-interacting protein kinase 2 | 7q32-q34 | 3.3 | L | PC |
| SWI-SNF(60-kd subunit) | Opposes chromatin-dependent repression of transcription | Hs.79335 | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 12q13-q14 | 3.2 | L | PC |
The table presents the murine gene name, the murine UniGene description, the Human UniGene Cluster ID, the name and UniGene description of the human gene, and the chromosome band (Band). FB indicates level of expression as measured relative to background (fold over background), as reported previously.17 Abundance category is based on the relative expression level over background, using the following definitions: L, low level (≥ 3-fold to < 10-fold over background); I, intermediate level (≥ 10-fold to < 25-fold); H, high level (≥ 25-fold to < 100-fold); and VH, very high level (≥ 100-fold). Characterization is based on a literature search, as described in the text: W, well characterized; PC, partially characterized; N, novel; N/A, not available.