Correlation of the FLT3 status to cytogenetics
| Karyotype . | Total (%) . | FLT3-LM negative (%) . | FLT3-LM positive (%) . | FLT-LM in karyotype group (%) . | P . |
|---|---|---|---|---|---|
| — | 1003 (100) | 769 (76.7) | 234 (23.3) | 23.3 | — |
| Normal | 428 (42.7) | 244 (31.7) | 165 (70.5) | 38.6 | < .0001 |
| t(15;17) | 68 (6.8) | 41 (5.3) | 24 (10.2) | 35.3 | .0131 |
| t(8;21) | 69 (6.9) | 61 (7.9) | 6 (2.6) | 8.7 | .0063 |
| inv(16) | 47 (4.7) | 42 (5.5) | — | — | .0002 |
| t(11q23) | 36 (3.6) | 32 (4.2) | 1 (0.4) | 2.8 | .0062 |
| Rare (t) | 23 (2.3) | 17 (2.2) | 1 (0.4) | 4.3 | .0758 |
| Complex | 120 (12.0) | 105 (13.7) | 3 (1.3) | 3.7 | < .0001 |
| − 5/− 7/7q− | 28 (2.8) | 27 (3.5) | 1 (0.4) | 3.6 | < .0001 |
| Others | 184 (18.3) | 151 (24.8) | 33 (14.1) | 17.9 | .1071 |
| Karyotype . | Total (%) . | FLT3-LM negative (%) . | FLT3-LM positive (%) . | FLT-LM in karyotype group (%) . | P . |
|---|---|---|---|---|---|
| — | 1003 (100) | 769 (76.7) | 234 (23.3) | 23.3 | — |
| Normal | 428 (42.7) | 244 (31.7) | 165 (70.5) | 38.6 | < .0001 |
| t(15;17) | 68 (6.8) | 41 (5.3) | 24 (10.2) | 35.3 | .0131 |
| t(8;21) | 69 (6.9) | 61 (7.9) | 6 (2.6) | 8.7 | .0063 |
| inv(16) | 47 (4.7) | 42 (5.5) | — | — | .0002 |
| t(11q23) | 36 (3.6) | 32 (4.2) | 1 (0.4) | 2.8 | .0062 |
| Rare (t) | 23 (2.3) | 17 (2.2) | 1 (0.4) | 4.3 | .0758 |
| Complex | 120 (12.0) | 105 (13.7) | 3 (1.3) | 3.7 | < .0001 |
| − 5/− 7/7q− | 28 (2.8) | 27 (3.5) | 1 (0.4) | 3.6 | < .0001 |
| Others | 184 (18.3) | 151 (24.8) | 33 (14.1) | 17.9 | .1071 |
P values: frequency of the mutation within the cytogenetic subgroup compared with the total cohort. Ordinal χ2 analysis shows that FLT3-LM is not randomly distributed within cytogenetic subgroups (P < .0001).