Patients' presenting features, according to level of residual disease on day 19
| Presenting feature . | Level of residual disease . | P* . | |||
|---|---|---|---|---|---|
| < 0.01% . | 0.01%-< 0.1% . | 0.1%-< 1.0% . | ≥ 1.0% . | ||
| Age (y) | |||||
| < 1 | 4 (3.5) | 0 (0) | 3 (8.3) | 2 (4.3) | .2952 |
| 1 to 9 | 76 (66.7) | 34 (66.7) | 19 (52.8) | 26 (55.3) | |
| ≥ 10 | 34 (29.8) | 17 (33.3) | 14 (38.9) | 19 (40.4) | |
| Sex | |||||
| Male | 58 (50.9) | 30 (58.8) | 19 (52.8) | 36 (76.6) | .0211 |
| Female | 56 (49.1) | 21 (41.2) | 17 (47.2) | 11 (23.4) | |
| Race | |||||
| White | 90 (78.9) | 37 (72.6) | 25 (69.4) | 29 (61.7) | .3242 |
| Black | 13 (11.4) | 10 (19.6) | 6 (16.7) | 11 (23.4) | |
| Other | 11 (9.7) | 4 (7.8) | 5 (13.9) | 7 (14.9) | |
| WBC count | |||||
| < 50 × 109/L | 87 (76.3) | 35 (68.6) | 24 (66.7) | 28 (60.0) | .1769 |
| ≥ 50 × 109/L | 27 (23.7) | 16 (31.4) | 12 (33.3) | 19 (40.4) | |
| CNS status | |||||
| 2 or 3 | 37 (32.5) | 18 (35.3) | 12 (33.3) | 18 (38.3) | .9058 |
| 1 | 77 (67.5) | 33 (64.7) | 24 (66.7) | 29 (61.7) | |
| Lineage | |||||
| T | 20 (17.5) | 13 (25.5) | 9 (25.0) | 14 (29.8) | .3054 |
| B | 94 (82.5) | 38 (74.5) | 27 (75.0) | 33 (70.2) | |
| DNA index | |||||
| ≥ 1.16 | 31 (27.2) | 11 (21.6) | 6 (16.7) | 6 (12.8) | .2050 |
| Other | 83 (72.8) | 40 (78.4) | 30 (83.3) | 41 (87.2) | |
| Ploidy† | |||||
| 51-65 chromosomes | 33 (17.2) | 15 (7.8) | 10 (5.2) | 8 (4.2) | .5627 |
| Others | 61 (31.8) | 23 (12.0) | 17 (8.9) | 25 (13.0) | |
| Ph chromosome‡ | |||||
| Absent | 114 (100) | 49 (96.1) | 35 (97.2) | 40 (85.1) | < .0001 |
| Present | 0 (0) | 0 (0) | 1 (2.8) | 6 (12.8) | |
| t(1;19)/E2A-PBX1‡ | |||||
| Absent | 112 (98.2) | 49 (96.1) | 34 (94.4) | 43 (91.5) | .2031 |
| Present | 2 (1.8) | 0 (0) | 2 (5.6) | 2 (4.3) | |
| t(4;11)/MLLrearrangement‡ | |||||
| Absent | 110 (96.5) | 49 (96.1) | 34 (94.4) | 43 (91.5) | .3861 |
| Present | 4 (3.5) | 0 (0) | 2 (5.6) | 2 (4.3) | |
| TEL/AML1‡ | |||||
| Absent | 81 (71.1) | 37 (72.5) | 28 (77.8) | 37 (78.7) | .0496 |
| Present | 20 (17.5) | 7 (13.7) | 3 (8.3) | 1 (2.1) | |
| NCI risk† | |||||
| Standard | 52 (57.8) | 23 (60.5) | 13 (52.0) | 16 (51.6) | .4700 |
| High | 38 (42.2) | 15 (39.5) | 12 (48.0) | 15 (48.4) | |
| Presenting feature . | Level of residual disease . | P* . | |||
|---|---|---|---|---|---|
| < 0.01% . | 0.01%-< 0.1% . | 0.1%-< 1.0% . | ≥ 1.0% . | ||
| Age (y) | |||||
| < 1 | 4 (3.5) | 0 (0) | 3 (8.3) | 2 (4.3) | .2952 |
| 1 to 9 | 76 (66.7) | 34 (66.7) | 19 (52.8) | 26 (55.3) | |
| ≥ 10 | 34 (29.8) | 17 (33.3) | 14 (38.9) | 19 (40.4) | |
| Sex | |||||
| Male | 58 (50.9) | 30 (58.8) | 19 (52.8) | 36 (76.6) | .0211 |
| Female | 56 (49.1) | 21 (41.2) | 17 (47.2) | 11 (23.4) | |
| Race | |||||
| White | 90 (78.9) | 37 (72.6) | 25 (69.4) | 29 (61.7) | .3242 |
| Black | 13 (11.4) | 10 (19.6) | 6 (16.7) | 11 (23.4) | |
| Other | 11 (9.7) | 4 (7.8) | 5 (13.9) | 7 (14.9) | |
| WBC count | |||||
| < 50 × 109/L | 87 (76.3) | 35 (68.6) | 24 (66.7) | 28 (60.0) | .1769 |
| ≥ 50 × 109/L | 27 (23.7) | 16 (31.4) | 12 (33.3) | 19 (40.4) | |
| CNS status | |||||
| 2 or 3 | 37 (32.5) | 18 (35.3) | 12 (33.3) | 18 (38.3) | .9058 |
| 1 | 77 (67.5) | 33 (64.7) | 24 (66.7) | 29 (61.7) | |
| Lineage | |||||
| T | 20 (17.5) | 13 (25.5) | 9 (25.0) | 14 (29.8) | .3054 |
| B | 94 (82.5) | 38 (74.5) | 27 (75.0) | 33 (70.2) | |
| DNA index | |||||
| ≥ 1.16 | 31 (27.2) | 11 (21.6) | 6 (16.7) | 6 (12.8) | .2050 |
| Other | 83 (72.8) | 40 (78.4) | 30 (83.3) | 41 (87.2) | |
| Ploidy† | |||||
| 51-65 chromosomes | 33 (17.2) | 15 (7.8) | 10 (5.2) | 8 (4.2) | .5627 |
| Others | 61 (31.8) | 23 (12.0) | 17 (8.9) | 25 (13.0) | |
| Ph chromosome‡ | |||||
| Absent | 114 (100) | 49 (96.1) | 35 (97.2) | 40 (85.1) | < .0001 |
| Present | 0 (0) | 0 (0) | 1 (2.8) | 6 (12.8) | |
| t(1;19)/E2A-PBX1‡ | |||||
| Absent | 112 (98.2) | 49 (96.1) | 34 (94.4) | 43 (91.5) | .2031 |
| Present | 2 (1.8) | 0 (0) | 2 (5.6) | 2 (4.3) | |
| t(4;11)/MLLrearrangement‡ | |||||
| Absent | 110 (96.5) | 49 (96.1) | 34 (94.4) | 43 (91.5) | .3861 |
| Present | 4 (3.5) | 0 (0) | 2 (5.6) | 2 (4.3) | |
| TEL/AML1‡ | |||||
| Absent | 81 (71.1) | 37 (72.5) | 28 (77.8) | 37 (78.7) | .0496 |
| Present | 20 (17.5) | 7 (13.7) | 3 (8.3) | 1 (2.1) | |
| NCI risk† | |||||
| Standard | 52 (57.8) | 23 (60.5) | 13 (52.0) | 16 (51.6) | .4700 |
| High | 38 (42.2) | 15 (39.5) | 12 (48.0) | 15 (48.4) | |
Values are numbers (%) of patients unless otherwise indicated.
WBC indicates white blood cell; CNS, central nervous system; Ph, Philadelphia; and NCI, National Cancer Institute.
With χ2 test and Fisher exact test, if necessary.
Only for patients with B-lineage ALL and age at diagnosis of over 1 year.
Data were missing in some cases.