Dogs given 213Bi-anti-CD45 mAb (0.5 mg/kg) and DLA-identical marrow grafts
| Dog . | Weight (kg) . | Anti-CD45 mAb (mg/kg) . | 213Bi (mCi/kg) . | [MBq/kg] . | Marrow MNCs (× 108/kg) . | GVHD . | Donor chimerism in MNCs (% range) . | Survival (wk)* . |
|---|---|---|---|---|---|---|---|---|
| E889 (R) | 10.8 | 0.5 | 4.6 | [170] | 5.3 | No | 30-70 | > 39 |
| E886 (D) | ||||||||
| E805 (R) | 11.2 | 0.5 | 3.6 | [133] | 4.4 | No | 40-50 | > 39 |
| E806 (D) | ||||||||
| E885 (R) | 6.3 | 0.5 | 8.8 | [326] | 4.5 | No | 40-95 | > 27 |
| E893 (D) |
| Dog . | Weight (kg) . | Anti-CD45 mAb (mg/kg) . | 213Bi (mCi/kg) . | [MBq/kg] . | Marrow MNCs (× 108/kg) . | GVHD . | Donor chimerism in MNCs (% range) . | Survival (wk)* . |
|---|---|---|---|---|---|---|---|---|
| E889 (R) | 10.8 | 0.5 | 4.6 | [170] | 5.3 | No | 30-70 | > 39 |
| E886 (D) | ||||||||
| E805 (R) | 11.2 | 0.5 | 3.6 | [133] | 4.4 | No | 40-50 | > 39 |
| E806 (D) | ||||||||
| E885 (R) | 6.3 | 0.5 | 8.8 | [326] | 4.5 | No | 40-95 | > 27 |
| E893 (D) |
213Bi indicates bismuth 213; mAb, monoclonal antibody; MNCs, mononuclear cells; GVHD, graft-versus-host disease; R, recipient; and D, donor.
All dogs were euthanized on completion of the study.