Disease-free survival
Cohort . | Any cGVHD . | Lim, ext . | Mild, mod, sev . | Low, int, high . | ||||
---|---|---|---|---|---|---|---|---|
RR6-150 . | 95% CI . | RR6-150 . | 95% CI . | RR6-150 . | 95% CI . | RR6-150 . | 95% CI . | |
IBMTR-1 | 1.0 | (0.8-1.2) | 0.66-154 | (0.4-0.8) | 0.56-155 | (0.4-0.7) | 0.56-154 | (0.4-0.7) |
1.3 | (1.0-1.6) | 1.06-154 | (0.7-1.3) | 1.16-154 | (0.8-1.4) | |||
2.9 | (2.2-3.9) | 2.0 | (1.5-2.7) | |||||
IBMTR-2 | 1.36-151 | (1.0-1.7) | 0.96-155 | (0.6-1.3) | 0.8 | (0.5-1.1) | 0.86-154 | (0.6-1.2) |
1.8 | (1.3-2.4) | 1.16-154 | (0.8-1.7) | 2.0 | (1.4-3.0) | |||
4.5 | (3.1-6.5) | 2.2 | (1.5-3.3) | |||||
NMDP | 1.56-152 | (1.1-1.9) | 1.2 | (0.8-1.7) | N/A | 0.7 | (0.4-1.2) | |
1.5 | (1.2-2.0) | 1.26-153 | (0.8-1.7) | |||||
2.0 | (1.3-3.1) |
Cohort . | Any cGVHD . | Lim, ext . | Mild, mod, sev . | Low, int, high . | ||||
---|---|---|---|---|---|---|---|---|
RR6-150 . | 95% CI . | RR6-150 . | 95% CI . | RR6-150 . | 95% CI . | RR6-150 . | 95% CI . | |
IBMTR-1 | 1.0 | (0.8-1.2) | 0.66-154 | (0.4-0.8) | 0.56-155 | (0.4-0.7) | 0.56-154 | (0.4-0.7) |
1.3 | (1.0-1.6) | 1.06-154 | (0.7-1.3) | 1.16-154 | (0.8-1.4) | |||
2.9 | (2.2-3.9) | 2.0 | (1.5-2.7) | |||||
IBMTR-2 | 1.36-151 | (1.0-1.7) | 0.96-155 | (0.6-1.3) | 0.8 | (0.5-1.1) | 0.86-154 | (0.6-1.2) |
1.8 | (1.3-2.4) | 1.16-154 | (0.8-1.7) | 2.0 | (1.4-3.0) | |||
4.5 | (3.1-6.5) | 2.2 | (1.5-3.3) | |||||
NMDP | 1.56-152 | (1.1-1.9) | 1.2 | (0.8-1.7) | N/A | 0.7 | (0.4-1.2) | |
1.5 | (1.2-2.0) | 1.26-153 | (0.8-1.7) | |||||
2.0 | (1.3-3.1) |
For abbreviations see Table 3.
Adjusted for disease type (acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia), disease stage (early, intermediate, advanced), age (years), patient-donor sex matching, and presence of prior acute GVHD (yes, no).
P ≤ .01 compared with no cGVHD.
P ≤ .001 compared with no cGVHD.
P ≤ .01 compared with the next most severe category.
P ≤ .001 compared with the next most severe category.
P ≤ .0001 compared with the next most severe category.