Table 6.

Disease-free survival

CohortAny cGVHDLim, extMild, mod, sevLow, int, high
RR6-15095% CIRR6-15095% CIRR6-15095% CIRR6-15095% CI
IBMTR-1 1.0 (0.8-1.2) 0.66-154 (0.4-0.8) 0.56-155 (0.4-0.7) 0.56-154 (0.4-0.7) 
   1.3 (1.0-1.6) 1.06-154 (0.7-1.3) 1.16-154 (0.8-1.4) 
     2.9 (2.2-3.9) 2.0 (1.5-2.7) 
IBMTR-2 1.36-151 (1.0-1.7) 0.96-155 (0.6-1.3) 0.8 (0.5-1.1) 0.86-154 (0.6-1.2) 
   1.8 (1.3-2.4) 1.16-154 (0.8-1.7) 2.0 (1.4-3.0) 
     4.5 (3.1-6.5) 2.2 (1.5-3.3) 
NMDP 1.56-152 (1.1-1.9) 1.2 (0.8-1.7) N/A  0.7 (0.4-1.2) 
   1.5 (1.2-2.0)   1.26-153 (0.8-1.7) 
       2.0 (1.3-3.1) 
CohortAny cGVHDLim, extMild, mod, sevLow, int, high
RR6-15095% CIRR6-15095% CIRR6-15095% CIRR6-15095% CI
IBMTR-1 1.0 (0.8-1.2) 0.66-154 (0.4-0.8) 0.56-155 (0.4-0.7) 0.56-154 (0.4-0.7) 
   1.3 (1.0-1.6) 1.06-154 (0.7-1.3) 1.16-154 (0.8-1.4) 
     2.9 (2.2-3.9) 2.0 (1.5-2.7) 
IBMTR-2 1.36-151 (1.0-1.7) 0.96-155 (0.6-1.3) 0.8 (0.5-1.1) 0.86-154 (0.6-1.2) 
   1.8 (1.3-2.4) 1.16-154 (0.8-1.7) 2.0 (1.4-3.0) 
     4.5 (3.1-6.5) 2.2 (1.5-3.3) 
NMDP 1.56-152 (1.1-1.9) 1.2 (0.8-1.7) N/A  0.7 (0.4-1.2) 
   1.5 (1.2-2.0)   1.26-153 (0.8-1.7) 
       2.0 (1.3-3.1) 

For abbreviations see Table 3.

F6-150

Adjusted for disease type (acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia), disease stage (early, intermediate, advanced), age (years), patient-donor sex matching, and presence of prior acute GVHD (yes, no).

F6-151

P ≤ .01 compared with no cGVHD.

F6-152

P ≤ .001 compared with no cGVHD.

F6-153

P ≤ .01 compared with the next most severe category.

F6-155

P ≤ .001 compared with the next most severe category.

F6-154

P ≤ .0001 compared with the next most severe category.

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