Kit inhibitory profiles of various kinase inhibitors
| KIT . | STI571 . | Staurosporine derivative (PKC412) . | Quinoxaline tryphosphatins (AG1296) . | Early indolinones (SU4984, SU6577) . | Multitargeted indolinones (SU11652/654/655) . |
|---|---|---|---|---|---|
| Wild type | Yes | Yes | Yes | Yes | Yes |
| JM domain mutant | Yes | ND | ND | Yes | Yes |
| Catalytic domain mutant | No | ND | ND | Only at high (10-μM) concentrations | Yes |
| KIT . | STI571 . | Staurosporine derivative (PKC412) . | Quinoxaline tryphosphatins (AG1296) . | Early indolinones (SU4984, SU6577) . | Multitargeted indolinones (SU11652/654/655) . |
|---|---|---|---|---|---|
| Wild type | Yes | Yes | Yes | Yes | Yes |
| JM domain mutant | Yes | ND | ND | Yes | Yes |
| Catalytic domain mutant | No | ND | ND | Only at high (10-μM) concentrations | Yes |
ND indicates not done.