Table 1. Target profiles of different... | American Society of Hematology

Table 1.

Target profiles of different indolinones

Compound	Ki (μM)				Cell kinase IC₅₀ (μM)
Compound	Flk-1	PDGFR	FGFR1	EGFR^*a	Flk-1	PDGFR	c-kit
SU5416	0.16	0.32	19.5	> 100	0.05	0.3	0.1
SU6668	2.1	0.008	1.2	> 100	0.5	1.0	0.5
SU11654	0.006	0.005	0.5	> 10	0.03	0.01	0.05

Compound	Ki (μM)				Cell kinase IC₅₀ (μM)
Compound	Flk-1	PDGFR	FGFR1	EGFR^*a	Flk-1	PDGFR	c-kit
SU5416	0.16	0.32	19.5	> 100	0.05	0.3	0.1
SU6668	2.1	0.008	1.2	> 100	0.5	1.0	0.5
SU11654	0.006	0.005	0.5	> 10	0.03	0.01	0.05

Ki indicates inhibitor constant.

Values for EGFR are IC₅₀.