Cytotoxic responses of allogeneic T cells of patients with CLL
| APC DCs . | Effector T cells . | Pulsed apoptotic cells . | Target cells . | Lysis, % . | |||
|---|---|---|---|---|---|---|---|
| Unstimulated CLL cells . | CD40-CLL cells . | K562 . | Unrelated CLL cells . | ||||
| CLL9 | CLL9 | CLL16 | CLL16 | 14 | 80 | 2 | 6 |
| CLL8 | CLL8 | CLL17 | CLL17 | 0 | 52 | 3 | 6 |
| CLL6 | CLL6 | CLL17 | CLL17 | 47 | 72 | 3 | 3 |
| APC DCs . | Effector T cells . | Pulsed apoptotic cells . | Target cells . | Lysis, % . | |||
|---|---|---|---|---|---|---|---|
| Unstimulated CLL cells . | CD40-CLL cells . | K562 . | Unrelated CLL cells . | ||||
| CLL9 | CLL9 | CLL16 | CLL16 | 14 | 80 | 2 | 6 |
| CLL8 | CLL8 | CLL17 | CLL17 | 0 | 52 | 3 | 6 |
| CLL6 | CLL6 | CLL17 | CLL17 | 47 | 72 | 3 | 3 |
Specific cytotoxicity of T cells against unstimulated and CD40-activated CLL cells after 4 stimulations with autologous DCs pulsed with apoptotic bodies of allogeneic CLL cells. The percent of lysis represents the mean of triplicates with an effector-target ratio of 1:30. SD was less than ± 10% in all experiments shown.