Nucleotide sequences of the clonotypic IgH rearrangements in a hyperdiploid ALL
| Rearrangements . | V . | N . | . | D . | . | N . | . | J . | Gene segments . | Open reading frame . |
|---|---|---|---|---|---|---|---|---|---|---|
| i | − 4 | aaggggg | − 5 | J5 | DH3-22/J5 | |||||
| gtattactatgatagtagtggttatta | ||||||||||
| ii | VH3 | aaaag | − 8 | atgatagtagtggttatta | − 4 | aaggggg | − 5 | J5 | VH3/DH3-22/J5 | (−) |
| iii | VH3 | gat | − 3 | atattgtagtagtaccagctgctatc | − 1 | − 2 | J4 | VH3/DH2-2/J4 | (−) |
| Rearrangements . | V . | N . | . | D . | . | N . | . | J . | Gene segments . | Open reading frame . |
|---|---|---|---|---|---|---|---|---|---|---|
| i | − 4 | aaggggg | − 5 | J5 | DH3-22/J5 | |||||
| gtattactatgatagtagtggttatta | ||||||||||
| ii | VH3 | aaaag | − 8 | atgatagtagtggttatta | − 4 | aaggggg | − 5 | J5 | VH3/DH3-22/J5 | (−) |
| iii | VH3 | gat | − 3 | atattgtagtagtaccagctgctatc | − 1 | − 2 | J4 | VH3/DH2-2/J4 | (−) |
Trimming of the rearranged segments is indicated by the numbers of nucleotides adjacent to DH or JH segments; underlined sequences indicate homology between rearrangements.