Chimerism and tumor responses of the 11 patients with hematologic malignancies treated with a sibling graft
Patient no. . | Disease . | Donor chimerism . | Disease state at 8 wk . | Survival days . | ||||
---|---|---|---|---|---|---|---|---|
Wk 1 . | Wk 2 . | Wk 3 . | Wk 4 . | Wk 8 . | ||||
1 | Lymphoma | 5% | 0 | 0 | 0 | 0 | CR | 12853-150 |
2 | Lymphoma | 10% | 10% | Not obtained | Patient died of progressive disease | 28 | ||
6 | Myeloma | 0 | 0 | Not obtained | 100% | 100% | CR | 116 |
8 | Myeloma | 10% | 10% | 0 | 0 | 0 | Stable | 229 |
9 | CML | 0 | 0 | 67% | 5% | 5% | No response | 129 |
11 | Lymphoma | 5% | Not obtained | Not obtained | Patient died of progressive disease | 29 | ||
12 | Lymphoma | 10% | 40% | 90% | 100% | 100% | CR | 222 |
20 | Lymphoma | 0 | 0 | 0 | 67% | Patient died of progressive disease | 37 | |
23 | CLL | 0 | 0 | 0 | 0 | 0 | PR | 179 |
24 | Lymphoma | 0 | 0 | 0 | 0 | Patient died of progressive disease | 40 | |
25 | AML | 0 | 100% | 100% | 100% | 100% | CR | 6303-150 |
Patient no. . | Disease . | Donor chimerism . | Disease state at 8 wk . | Survival days . | ||||
---|---|---|---|---|---|---|---|---|
Wk 1 . | Wk 2 . | Wk 3 . | Wk 4 . | Wk 8 . | ||||
1 | Lymphoma | 5% | 0 | 0 | 0 | 0 | CR | 12853-150 |
2 | Lymphoma | 10% | 10% | Not obtained | Patient died of progressive disease | 28 | ||
6 | Myeloma | 0 | 0 | Not obtained | 100% | 100% | CR | 116 |
8 | Myeloma | 10% | 10% | 0 | 0 | 0 | Stable | 229 |
9 | CML | 0 | 0 | 67% | 5% | 5% | No response | 129 |
11 | Lymphoma | 5% | Not obtained | Not obtained | Patient died of progressive disease | 29 | ||
12 | Lymphoma | 10% | 40% | 90% | 100% | 100% | CR | 222 |
20 | Lymphoma | 0 | 0 | 0 | 67% | Patient died of progressive disease | 37 | |
23 | CLL | 0 | 0 | 0 | 0 | 0 | PR | 179 |
24 | Lymphoma | 0 | 0 | 0 | 0 | Patient died of progressive disease | 40 | |
25 | AML | 0 | 100% | 100% | 100% | 100% | CR | 6303-150 |
CML indicates chronic myelogenous leukemia.
Patient alive at last follow-up of December 31, 2001.