Table 2.

MFGS-gc transduction of X-linked severe combined immunodeficiency B-cell lines

XSCID phenotypeN*Appearance or increase (%) of γc on cells after transduction with MFGS-gc with envelopeGeometric mean channel increase
AmphotropicGALVRD114AmphotropicGALVRD114
γc (Pt 1, 2) 14 ± 9 17 ± 9 39 ± 16 167 ± 46 179 ± 42 209 ± 37 
γc+ (Pt 3) 2 ± 1 0 ± 0 13 ± 16 41 ± 58 50 ± 51 114 ± 13 
XSCID phenotypeN*Appearance or increase (%) of γc on cells after transduction with MFGS-gc with envelopeGeometric mean channel increase
AmphotropicGALVRD114AmphotropicGALVRD114
γc (Pt 1, 2) 14 ± 9 17 ± 9 39 ± 16 167 ± 46 179 ± 42 209 ± 37 
γc+ (Pt 3) 2 ± 1 0 ± 0 13 ± 16 41 ± 58 50 ± 51 114 ± 13 

XSCID indicates X-linked severe combined immunodeficiency; GALV, gibbon ape leukemia virus; Pt, patient.

*

Number of experiments.

Mean ± SD of increase in proportion of γc+ cells.

Mean ± SD of increase of mean fluorescence channel of γc+ cells.

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