RHD alleles described in this study
| Trivial name . | Allele . | Nucleotide change . | Effect on protein sequence . | Exon involved . | Number of probands . | Ethnic origin . |
|---|---|---|---|---|---|---|
| DAU-0 | RHD(T379M) | 1136 C > T | Thr to Met at 379 | 8 | 3 | European* |
| DAU-1 | RHD (S230I,T379M) | 689 G > T | Ser to Ile at 230 | 5 | 3 | African |
| 1136 C > T | Thr to Met at 379 | 8 | ||||
| DAU-2 | RHD (R70Q,S333N,T379M) | 209 G > A | Arg to Gln at 70 | 2 | 1 | African† |
| 998 G > A | Ser to Asn at 333 | 7 | ||||
| 1136 C > T | Thr to Met at 379 | 8 | ||||
| DAU-3 | RHD (V279M,T379M) | 835 G > A | Val to Met at 279 | 6 | 1 | African |
| 1136 C > T | Thr to Met at 379 | 8 | ||||
| DAU-4 | RHD(E233K,T379M) | 697 G > A | Glu to Lys at 233 | 5 | 1 | African† |
| 1136 C > T | Thr to Met at 379 | 8 |
| Trivial name . | Allele . | Nucleotide change . | Effect on protein sequence . | Exon involved . | Number of probands . | Ethnic origin . |
|---|---|---|---|---|---|---|
| DAU-0 | RHD(T379M) | 1136 C > T | Thr to Met at 379 | 8 | 3 | European* |
| DAU-1 | RHD (S230I,T379M) | 689 G > T | Ser to Ile at 230 | 5 | 3 | African |
| 1136 C > T | Thr to Met at 379 | 8 | ||||
| DAU-2 | RHD (R70Q,S333N,T379M) | 209 G > A | Arg to Gln at 70 | 2 | 1 | African† |
| 998 G > A | Ser to Asn at 333 | 7 | ||||
| 1136 C > T | Thr to Met at 379 | 8 | ||||
| DAU-3 | RHD (V279M,T379M) | 835 G > A | Val to Met at 279 | 6 | 1 | African |
| 1136 C > T | Thr to Met at 379 | 8 | ||||
| DAU-4 | RHD(E233K,T379M) | 697 G > A | Glu to Lys at 233 | 5 | 1 | African† |
| 1136 C > T | Thr to Met at 379 | 8 |
Detected in the local donor population of southwestern Germany; in addition, sequencing of the 95-012 DNA sample revealed heterozygosities for 509 T/C, 667 T/G, and 1136 C/T, suggestive of aDOL/DAU-0 genotype.
Samples referred without explicit information on ethnic origin; African descent inferred from African names.