Table 1. Effective concentrations of PDE... | American Society of Hematology

Table 1.

Effective concentrations of PDE inhibitors producing an EC₅₀ of cultured CEM cell number

Drug	EC₅₀alone	EC₅₀ with 1 μM DEX	Fold increase in DEX sensitivity
Aminophylline	180 μg/mL	54 μg/mL	3.3
Enprophylline	240 μg/mL	100 μg/mL	2.4
Caffeine	150 μg/mL	150 μg/mL	1
Pentoxifylline	350 μg/mL	350 μg/mL	1
Dyphylline	> 400 μg/mL	> 400 μg/mL	1
Rolipram	44 μM (12 μg/mL)	26 μM (7 μg/mL)	1.7

Drug	EC₅₀alone	EC₅₀ with 1 μM DEX	Fold increase in DEX sensitivity
Aminophylline	180 μg/mL	54 μg/mL	3.3
Enprophylline	240 μg/mL	100 μg/mL	2.4
Caffeine	150 μg/mL	150 μg/mL	1
Pentoxifylline	350 μg/mL	350 μg/mL	1
Dyphylline	> 400 μg/mL	> 400 μg/mL	1
Rolipram	44 μM (12 μg/mL)	26 μM (7 μg/mL)	1.7

DEX indicates dexamethasone.