Demographics of patients and distribution of glutathioneS-transferase genotypes
| Characteristic . | Total patients, n = 710 (%) . | GSTM1-null patients, n = 381 (%) . | P . | GSTT1-null patients, n = 115 (%) . | P . |
|---|---|---|---|---|---|
| Male | 389 (55) | 213 (56) | 60 (52) | ||
| Female | 321 (45) | 168 (44) | .6 | 55 (48) | .6 |
| Age at diagnosis | |||||
| < 1 y | 15 (2) | 11 (3) | 4 (4) | ||
| 1-2 y | 67 (9) | 40 (11) | 14 (12) | ||
| 2-10 y | 527 (74) | 284 (75) | 84 (73) | ||
| > 10 y | 101 (14) | 46 (12) | .1 | 13 (11) | .4 |
| WBC count at diagnosis, × 109/L | |||||
| < 10 | 333 (47) | 178 (47) | 55 (48) | ||
| 10-20 | 117 (16) | 67 (18) | 23 (20) | ||
| 20-50 | 109 (15) | 57 (15) | 19 (17) | ||
| 50-100 | 64 (9) | 34 (9) | 7 (6) | ||
| > 100 | 87 (12) | 45 (12) | .9 | 11 (10) | .5 |
| Race | |||||
| White | 616 (87) | 331 (87) | 96 (84) | ||
| Black | 35 (5) | 14 (4) | 6 (5) | ||
| Hispanic | 35 (5) | 19 (5) | 9 (8) | ||
| Asian | 6 (1) | 5 (1) | 1 (1) | ||
| Other/mixed | 18 (2.5) | 12 (3) | .2 | 3 (3) | .6 |
| Lineage | |||||
| B-lineage | 463 (65) | 242 (64) | 73 (63) | ||
| T-lineage | 95 (13) | 55 (14) | 15 (13) | ||
| Null | 1 (0.3) | 1 (0.3) | 1 (1) | ||
| Mixed lineage | 64 (9) | 37 (9.7) | 10 (9) | ||
| Undefined/missing | 87 (12) | 46 (12) | .7 | 16 (14) | .6 |
| CNS disease at diagnosis | |||||
| Yes | 25 (3) | 12 (3) | 2 (2) | ||
| No | 679 (96) | 368 (96.5) | 112 (97) | ||
| Missing | 6 (1) | 1 (0.5) | .2 | 1 (1) | .5 |
| Testicular disease at diagnosis (males) | |||||
| Yes | 14 (3.5) | 8 (3.5) | 5 (8) | ||
| No | 373 (96) | 204 (96) | 55 (92) | ||
| Missing | 2 (0.5) | 1 (0.5) | .8 | 0 | .1 |
| Cytogenetics (numerical) | |||||
| Normal | 104 (14) | 48 (13) | 16 (14) | ||
| Hyperdiploidy, no. of chromosomes (47-50) | 37 (5) | 16 (4) | 5 (4) | ||
| Hyperdiploidy, no. of chromosomes (> 50) | 84 (12) | 49 (13) | 10 (9) | ||
| Pseudodiploidy | 79 (11) | 48 (13) | 11 (10) | ||
| Hypodiploidy | 11 (1.5) | 7 (2) | 0 | ||
| Missing | 395 (56) | 213 (56) | .2 | 73 (63) | .7 |
| Cytogenetics (structural) | |||||
| Normal | 104 (15) | 48 (29) | 16 (38) | ||
| Multiple abnormalities | 186 (26) | 104 (62) | 21 (50) | ||
| t(1;19) | 12 (1.5) | 6 (4) | 2 (5) | ||
| t(4;11) | 8 (1) | 6 (4) | 2 (5) | ||
| t(9;22) | 4 (0.5) | 3 (2) | 1 (2.5) | ||
| t(8;14) | 1 (0.5) | 1 (1) | .3 | 0 (0) | .7 |
| Down syndrome | |||||
| Yes | 12 (2) | 6 (2) | 3 (3) | ||
| No | 698 (98) | 375 (98) | .9 | 112 (97) | .3 |
| Characteristic . | Total patients, n = 710 (%) . | GSTM1-null patients, n = 381 (%) . | P . | GSTT1-null patients, n = 115 (%) . | P . |
|---|---|---|---|---|---|
| Male | 389 (55) | 213 (56) | 60 (52) | ||
| Female | 321 (45) | 168 (44) | .6 | 55 (48) | .6 |
| Age at diagnosis | |||||
| < 1 y | 15 (2) | 11 (3) | 4 (4) | ||
| 1-2 y | 67 (9) | 40 (11) | 14 (12) | ||
| 2-10 y | 527 (74) | 284 (75) | 84 (73) | ||
| > 10 y | 101 (14) | 46 (12) | .1 | 13 (11) | .4 |
| WBC count at diagnosis, × 109/L | |||||
| < 10 | 333 (47) | 178 (47) | 55 (48) | ||
| 10-20 | 117 (16) | 67 (18) | 23 (20) | ||
| 20-50 | 109 (15) | 57 (15) | 19 (17) | ||
| 50-100 | 64 (9) | 34 (9) | 7 (6) | ||
| > 100 | 87 (12) | 45 (12) | .9 | 11 (10) | .5 |
| Race | |||||
| White | 616 (87) | 331 (87) | 96 (84) | ||
| Black | 35 (5) | 14 (4) | 6 (5) | ||
| Hispanic | 35 (5) | 19 (5) | 9 (8) | ||
| Asian | 6 (1) | 5 (1) | 1 (1) | ||
| Other/mixed | 18 (2.5) | 12 (3) | .2 | 3 (3) | .6 |
| Lineage | |||||
| B-lineage | 463 (65) | 242 (64) | 73 (63) | ||
| T-lineage | 95 (13) | 55 (14) | 15 (13) | ||
| Null | 1 (0.3) | 1 (0.3) | 1 (1) | ||
| Mixed lineage | 64 (9) | 37 (9.7) | 10 (9) | ||
| Undefined/missing | 87 (12) | 46 (12) | .7 | 16 (14) | .6 |
| CNS disease at diagnosis | |||||
| Yes | 25 (3) | 12 (3) | 2 (2) | ||
| No | 679 (96) | 368 (96.5) | 112 (97) | ||
| Missing | 6 (1) | 1 (0.5) | .2 | 1 (1) | .5 |
| Testicular disease at diagnosis (males) | |||||
| Yes | 14 (3.5) | 8 (3.5) | 5 (8) | ||
| No | 373 (96) | 204 (96) | 55 (92) | ||
| Missing | 2 (0.5) | 1 (0.5) | .8 | 0 | .1 |
| Cytogenetics (numerical) | |||||
| Normal | 104 (14) | 48 (13) | 16 (14) | ||
| Hyperdiploidy, no. of chromosomes (47-50) | 37 (5) | 16 (4) | 5 (4) | ||
| Hyperdiploidy, no. of chromosomes (> 50) | 84 (12) | 49 (13) | 10 (9) | ||
| Pseudodiploidy | 79 (11) | 48 (13) | 11 (10) | ||
| Hypodiploidy | 11 (1.5) | 7 (2) | 0 | ||
| Missing | 395 (56) | 213 (56) | .2 | 73 (63) | .7 |
| Cytogenetics (structural) | |||||
| Normal | 104 (15) | 48 (29) | 16 (38) | ||
| Multiple abnormalities | 186 (26) | 104 (62) | 21 (50) | ||
| t(1;19) | 12 (1.5) | 6 (4) | 2 (5) | ||
| t(4;11) | 8 (1) | 6 (4) | 2 (5) | ||
| t(9;22) | 4 (0.5) | 3 (2) | 1 (2.5) | ||
| t(8;14) | 1 (0.5) | 1 (1) | .3 | 0 (0) | .7 |
| Down syndrome | |||||
| Yes | 12 (2) | 6 (2) | 3 (3) | ||
| No | 698 (98) | 375 (98) | .9 | 112 (97) | .3 |
GSTM1 indicates glutathione S-transferase μ1; GSTT1, glutathione S-transferase θ1; WBC, white blood cell; CNS, central nervous system.