Most homologous germline gene segments used by human antibodies directed against the C2 domain
| Clone . | VH domain germline . | VL domain . | Reference . | |
|---|---|---|---|---|
| Germline . | Family . | |||
| WR1 | DP-5 (1-24) | DPK8 (L8) | VI | This study |
| WR17 | DPL5 (V1-19) | V1 | This study | |
| WR16 | DPK3 (L11) | VI | This study | |
| BO2C11 | DPK22 (A27) | VIII | 16 | |
| YK3-3-38 | — | — | 28 | |
| YK3-3-40 | — | — | 28 | |
| YK3-3-50 | — | — | 28 | |
| EL-14 | DP-10 (1-69) | DPK5 (L5) | VI | 13 |
| EL-5 | DP-14 (1-18) | L12a | VI | 13 |
| EL-16 | DPK8 (L8) | VI | 13 | |
| EL-25 | DPK7 (L15) | VI | 13 | |
| EL-9 | DP-88 (1-e) | DPK8 (L8) | VI | 13 |
| WR10 | DPL11 (V1-4) | V2 | This study | |
| WR2/7/13 | ND | ND | This study | |
| WR3 | DPK3 (L11) | VI | This study | |
| WR8 | DPK24 (B3) | VIV | This study | |
| WR9 | V1-2 (V1-2) | V2 | This study | |
| WR11 | DPL11 (V1-4) | V2 | This study | |
| WR15 | DPL16 (V2-13) | V3 | This study | |
| Clone . | VH domain germline . | VL domain . | Reference . | |
|---|---|---|---|---|
| Germline . | Family . | |||
| WR1 | DP-5 (1-24) | DPK8 (L8) | VI | This study |
| WR17 | DPL5 (V1-19) | V1 | This study | |
| WR16 | DPK3 (L11) | VI | This study | |
| BO2C11 | DPK22 (A27) | VIII | 16 | |
| YK3-3-38 | — | — | 28 | |
| YK3-3-40 | — | — | 28 | |
| YK3-3-50 | — | — | 28 | |
| EL-14 | DP-10 (1-69) | DPK5 (L5) | VI | 13 |
| EL-5 | DP-14 (1-18) | L12a | VI | 13 |
| EL-16 | DPK8 (L8) | VI | 13 | |
| EL-25 | DPK7 (L15) | VI | 13 | |
| EL-9 | DP-88 (1-e) | DPK8 (L8) | VI | 13 |
| WR10 | DPL11 (V1-4) | V2 | This study | |
| WR2/7/13 | ND | ND | This study | |
| WR3 | DPK3 (L11) | VI | This study | |
| WR8 | DPK24 (B3) | VIV | This study | |
| WR9 | V1-2 (V1-2) | V2 | This study | |
| WR11 | DPL11 (V1-4) | V2 | This study | |
| WR15 | DPL16 (V2-13) | V3 | This study | |
VH and VL germline gene use and nomenclature according to V-BASE.23 All observed VH germline genes belong to the VH1 gene family.
ND indicates not determined.