General characteristics of patients with APL at initiation of As4S4 therapy
| Characteristic . | Patients with newly diagnosed APL (n = 19) . | Patients with relapsed APL (n = 7) . | Patients with APL and HCR (n = 103) . |
|---|---|---|---|
| Sex: F/M | 8/11 | 6/1 | 51/52 |
| Median age, y (range) | 33 (16-63) | 43 (30-58) | 34 (14-63) |
| Median % of blasts and promyelocytes in BM (range) | 88 (43-93.5) | 67 (9-90) | < 5 |
| PML-RARα mRNA transcripts | |||
| Positive | 19 | 7 | 44 |
| Negative | 0 | 0 | 56 |
| Not available | 0 | 0 | 3 |
| Median WBC, × 109/L (range) | 2.3 (0.3-30.1) | 1.7 (0.7-9) | Normal range |
| WBC count higher than 10 × 109/L | 4 | 0 | — |
| WBC no more than 10 × 109/L | 15 | 7 | — |
| Median Hb, g/L (range) | 73 (45-116) | 88 (53-107) | Normal range |
| Median platelet count, × 109/L (range) | 39.7 (15-136) | 52 (1.7-93) | Normal range |
| Characteristic . | Patients with newly diagnosed APL (n = 19) . | Patients with relapsed APL (n = 7) . | Patients with APL and HCR (n = 103) . |
|---|---|---|---|
| Sex: F/M | 8/11 | 6/1 | 51/52 |
| Median age, y (range) | 33 (16-63) | 43 (30-58) | 34 (14-63) |
| Median % of blasts and promyelocytes in BM (range) | 88 (43-93.5) | 67 (9-90) | < 5 |
| PML-RARα mRNA transcripts | |||
| Positive | 19 | 7 | 44 |
| Negative | 0 | 0 | 56 |
| Not available | 0 | 0 | 3 |
| Median WBC, × 109/L (range) | 2.3 (0.3-30.1) | 1.7 (0.7-9) | Normal range |
| WBC count higher than 10 × 109/L | 4 | 0 | — |
| WBC no more than 10 × 109/L | 15 | 7 | — |
| Median Hb, g/L (range) | 73 (45-116) | 88 (53-107) | Normal range |
| Median platelet count, × 109/L (range) | 39.7 (15-136) | 52 (1.7-93) | Normal range |
As4S4 indicates trans-arsenic tetra-sulfide; APL, acute promyelocytic leukemia; HCR, hematologic complete remission; BM, bone marrow; WBC, white cell count; and Hb, hemoglobin.